Evidence map›Paper›PMID 33299824›Full record

ArticleCanadian journal of gastroenterology & hepatology2020

Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases.

Erica S Tsang, Jonathan M Loree, Janine M Davies, Sharlene Gill, David Liu, Stephen Ho, Daniel J Renouf, Howard J Lim, Hagen F Kennecke

Open access · goldAbstract read
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Role of Radioembolization in Metastatic Neuroendocrine Tumors.Cardiovascular and interventional radiology · 2022
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Erica S TsangDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0003-2317-2721
Jonathan M LoreeDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0001-8189-2132
Janine M DaviesDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0003-3834-6835
Sharlene GillDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0003-3306-3617
David LiuDepartment of Radiology, Vancouver General Hospital, Vancouver, BC, Canada.
Stephen HoDepartment of Radiology, Vancouver General Hospital, Vancouver, BC, Canada.
Daniel J RenoufDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0002-7597-6089
Howard J LimDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0002-5814-714X
Hagen F KenneckeFloyd and Delores Jones Cancer Institute, Virginia Mason Cancer Institute, Seattle, WA, USA.ORCID 0000-0002-3211-0656
Vancouver General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Yttrium-90 (Y-90) can be an effective liver-directed therapy for patients with metastatic neuroendocrine tumors (NETs), but population-based data are limited. We characterized the use of Y-90 in NET patients and identified factors associated with response. Methods: We identified 49 patients with metastatic liver-dominant NETs across BC Cancer's six regional centres who received Y-90 between June 2011 and January 2017 in British Columbia, Canada. Baseline characteristics, radiographic responses, and outcomes were summarized. Results: Of the 49 patients who received Y-90, the median age was 56 years (range 21-78), 49% were male, and 94% had an ECOG performance status of 0-1. The primary location of the NET included pancreas (31%), small bowel (41%), large bowel (6%), unknown (14%), and others (12%). 69% of these patients had liver metastases alone, and tumors were graded as Conclusions: In our population-based cohort, Y-90 was well-tolerated in patients with metastatic liver-dominant NETs. Prior surgical resection was an important predictor of OS.

Indexed as

Liver NeoplasmsNeuroendocrine TumorsAdultAgedBritish ColumbiaHumansMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeYoung AdultYttrium RadioisotopesYttrium-90Yttrium Radioisotopes

Identifiers

PMID33299824
PMCPMC7704205
OpenAlexW3106685942

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.