Evidence map›Paper›PMID 33299671›Full record

ArticleNeurology. Clinical practice2020

Quantitative sensory testing predicts histological small fiber neuropathy in postural tachycardia syndrome.

Sophia C I Billig, Joana C Schauermann, Roman Rolke, Istvan Katona, Jörg B Schulz, Andrea Maier

Open access · greenAbstract read
In one paragraph

Article in Neurology. Clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Hyperadrenergic and neuropathic features based on clinical autonomic testing in individuals with POTS: an observational cross-sectional study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
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  4. Review
  5. Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
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  11. Cutaneous alpha-synuclein deposition in postural tachycardia patients.Annals of clinical and translational neurology · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sophia C I BilligDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Joana C SchauermannDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Roman RolkeDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Istvan KatonaDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Jörg B SchulzDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Andrea MaierDepartment of Neurology (SCIB, JCS, AM, JBS), Department of Neuropathology (IK), Department of Palliative Care (RR), RWTH Aachen University; Research Training Group 2416 MultiSenses-MultiScales (JBS), Aachen; and Forschungszentrum Jülich GmbH (JBS), JARA-Brain Institute Molecular Neuroscience and Neuroimaging, Jülich, Germany.
Jülich Aachen Research Alliance · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetrospective investigation of the somatosensory profile and prediction of histologic small fiber neuropathy (SFN) in postural orthostatic tachycardia syndrome (POTS) was performed using quantitative sensory testing (QST) as a standardized noninvasive test.

methodsIn this investigation, full data sets from 30 patients (age: 34.03 ± 10.82 years, n = 6 males), including results of autonomic function testing, norepinephrine values, skin biopsy, and QST, were retrospectively analyzed. The QST data were compared with healthy controls (HCs) (age: 34.20 ± 10.5 years, n = 6 males,

resultsThe evaluation of all QST parameters in POTS compared with HCs yielded differences in all thermal parameters (cold detection threshold:

conclusionThese results suggest that a non-region-specific SFN in POTS compared with controls can be detected by noninvasive QST that predicts histologic small fiber pathology.

Identifiers

PMID33299671
PMCPMC7717634
OpenAlexW2986928916

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.