Evidence map›Paper›PMID 33299558›Full record

ArticleAnnals of medicine and surgery (2012)2020

Impact of HIV status and predictors of successful treatment outcomes among tuberculosis patients: A six-year retrospective cohort study.

Ginenus Fekadu, Ebisa Turi, Tinsae Kasu, Firomsa Bekele, Legese Chelkeba, Tadesse Tolossa, Busha Gamachu Labata, Dinka Dugassa, Getahun Fetensa, Dereje Chala Diriba

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Annals of medicine and surgery (2012), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044805 (Monitoring Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax Based on Clinical, Parasitologic and Hematologic Parameters in Shecha Health Center), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06044805 phase4completednot on this mapstarted 2022, after this paper: background citation

Monitoring Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax Based on Clinical, Parasitologic and Hematologic Parameters in Shecha Health Center: Open Label Clinical Trial

TypeinterventionalSponsorDinka DugassaRan2022 to 2023Enrolled100ConditionsEfficacy, Malaria, Chloroquine, Vivax MalariaArmsChloroquine, Primaquine
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  3. Within-host evolution of drug tolerance inJAC-antimicrobial resistance · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ginenus FekaduSchool of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Ebisa TuriDepartment of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Tinsae KasuDepartment of Production, Julphar Pharmaceuticals PLC, Addis Ababa, Ethiopia.
Firomsa BekeleDepartment of Pharmacy, College of Health Sciences, Mettu University, Mettu, Ethiopia.
Legese ChelkebaSchool of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Tadesse TolossaDepartment of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Busha Gamachu LabataSchool of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Dinka DugassaSchool of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Getahun FetensaSchool of Nursing and Midwifery, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Dereje Chala DiribaSchool of Nursing and Midwifery, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
Wollega University · ETAddis Ababa University · ETEthiopian Civil Service University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) remains a major global public health problem. Hence, the study aimed to assess the impact of human immune virus (HIV) status and predictors of successful treatment outcomes of TB patients enrolled at Nekemte specialized hospital. An institution-based retrospective cohort study was conducted and the data analyzed using SPSS version 24.0. A multivariable logistic regression model was fitted to identify the association between treatment outcome and potential predictor variables. The association was calculated using the Adjusted Odds ratio (AOR) and the statistical significance was considered at p < 0.05. Out of the total 506 study participants, 50.2% of them were males. The overall treatment success rate was 81.4% and 58.06% among HIV co-infected TB patients. Female sex (AOR = 2.01, 95%CI: 1.04-16.11), age 25-34 years (AOR = 3.982, 95%CI: 1.445-10.971), age 35-49 years (AOR = 5.392, 95%CI: 1.674-17.368), high school educational level (AOR = 5.330, 95% CI: 1.753-16.209), urban residence (AOR = 3.093, 95%CI: 1.003-9.541) and HIV negative (AOR = 10.3, 95%CI, 3.216-32.968) were positively associated with favorable TB treatment outcome. Whereas, being single (AOR = 0.293, 95%CI: 0.1-0.854), smear-negative pulmonary TB (AOR = 0.360, 95%CI: 0.156-0.834), extra-pulmonary TB (AOR = 0.839, 95%CI: 0.560-0.955) and retreatment case (AOR: 0.54, 95%CI: 0.004-0.098) were negatively associated with successful treatment outcome. The treatment success rate of TB patients was lower than World Health Organization target set of 85%. The increased unsuccessful outcome among TB/HIV patients requires urgent public health interventions to improve the evaluation policy and control framework.

Indexed as

EthiopiaPredictorTB-HIV Co-InfectionTB treatment OutcomeTreatment success rate

Identifiers

PMID33299558
PMCPMC7704363
OpenAlexW3104143073

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.