Evidence map›Paper›PMID 33299500›Full record

ArticleDisease markers2020

Identification of Circulating lncRNA Expression Profiles in Patients with Atrial Fibrillation.

Zhong-Bao Ruan, Fei Wang, Bing-di Gongben, Ge-Cai Chen, Li Zhu

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  6. Non-coding RNA and arrhythmias: expression, function, and molecular mechanism.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhong-Bao RuanDepartment of Cardiology, Jiangsu Taizhou People's Hospital, Taizhou 225300, China.ORCID https://orcid.org/0000-0003-0607-0010
Fei WangDepartment of Cardiology, Jiangsu Taizhou People's Hospital, Taizhou 225300, China.ORCID https://orcid.org/0000-0002-0403-8845
Bing-di GongbenDepartment of Cardiology, Jiangsu Taizhou People's Hospital, Taizhou 225300, China.ORCID https://orcid.org/0000-0002-8791-8708
Ge-Cai ChenDepartment of Cardiology, Jiangsu Taizhou People's Hospital, Taizhou 225300, China.ORCID https://orcid.org/0000-0003-4157-3190
Li ZhuDepartment of Cardiology, Jiangsu Taizhou People's Hospital, Taizhou 225300, China.ORCID https://orcid.org/0000-0003-2931-0750
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF).

methodsThe peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to 2017.08. Reverse transcription polymerase chain reaction (RT-PCR) was applied for further verification. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify the functions of differentially expressed genes and related pathways.

resultsThere were 19 lncRNAs differentially expressed (FC ≥ 2,

conclusionsThe expression of lncRNA in peripheral blood of AF patients is different from that of normal people. The physiological functions of these differentially expressed lncRNAs may be related to the pathogenesis of AF, which provide experimental basis and new therapeutic target for prognosis and treatment of patients with AF. HNRNPU-AS1 may play an important role in the pathophysiology and mechanisms of AF.

Indexed as

Up-RegulationAgedAtrial FibrillationCase-Control StudiesCell-Free Nucleic AcidsFemaleGene Expression ProfilingGene Regulatory NetworksHumansMaleMiddle AgedOligonucleotide Array Sequence AnalysisRNA, Long NoncodingSequence Analysis, RNACell-Free Nucleic AcidsRNA, Long Noncoding

Identifiers

PMID33299500
PMCPMC7704132
OpenAlexW3107056662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.