Evidence map›Paper›PMID 33299319›Full record

ArticleVascular health and risk management2020

Expression of Hypoxia-Inducible Factor-1α (HIF1A) and Lp-PLA2 in Low, Intermediate, and High Cardiovascular Disease Risk Population.

Teuku Heriansyah, Indah Nur Chomsy, Kumboyono Kumboyono, Pinandita Annisa Pratiwi, Titin Andri Wihastuti

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular health and risk management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Effects of swimming on the development of atherosclerosis in mice.American journal of translational research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Teuku HeriansyahDepartment of Cardiology and Vascular Medicine, Syiah Kuala University, Banda Aceh 23111, Indonesia.ORCID 0000-0002-0363-1997
Indah Nur ChomsyMaster Program in Biomedical Science, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.ORCID 0000-0002-1050-3571
Kumboyono KumboyonoNursing Department, Faculty of Medicine, University of Brawijaya, Malang 65145, Indonesia.ORCID 0000-0003-2124-8673
Pinandita Annisa PratiwiMedical Study Program, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.
Titin Andri WihastutiDepartment of Biomedicine, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia.ORCID 0000-0001-6476-0541
University of Brawijaya · IDUniversitas Syiah Kuala · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathomechanism of CVD is a complex and multifactorial process. The primary mechanism of CVD is atherosclerosis. Inflammation in atherogenesis raises the risk of hypoxia, which will activate hypoxia-inducible factor-1α (HIF1A). Also, together with lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammatory mediator for atherogenesis. PURPOSE: This study aims to measure the hypoxia-inducible factor-1α (HIF1A) expression and its correlation to Lp-PLA2 expression at low-risk, intermediate, and high-risk CVD populations. PATIENTS AND

methodsThe study used a correlational analysis method with a total sampling technique in 160 individuals in the risk population. The atherosclerosis risk group was analyzed using the Framingham Risk Score and categorized into low, intermediate, and high-risk groups. Venous blood samples taken from respondents were measured using the ELISA method with Lp-PLA2 and HIF-1α as parameters. Data were analyzed using normality test, homogeneity test, one-way ANOVA, post hoc-Tukey HSD, and Pearson correlation.

resultsThe concentration of HIF1A had a very strong correlation with Lp-PLA2 expression, both in the low-risk group (r = 0.512), intermediate (r = 0.512), and high (r = 0.715) (P <0.05). However, the concentrations of Lp-PLA2 did not match the FRS.

conclusionHIF1A expression increased with increasing risk, while Lp-PLA2 expression decreased with increasing risk of atherosclerosis based on the FRS category. There is a significant correlation between HIF1A expression and Lp-PLA2 expression based on FRS.

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseAdultAgedAged, 80 and overAtherosclerosisBiomarkersCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHeart Disease Risk FactorsHumansHypoxia-Inducible Factor 1, alpha SubunitIndonesiaMaleMiddle AgedPredictive Value of Tests1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitPLA2G7 protein, humanatherosclerosiscardiovascular diseaseFramingham Risk ScoreHIF1ALp-PLA2

Identifiers

PMID33299319
PMCPMC7720284
OpenAlexW3109632039

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.