ArticleNature2021
H1 histones control the epigenetic landscape by local chromatin compaction.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
108 citing papers in PubMed, 191 citations in OpenAlex.
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- Linker Histones: The Multiple Binding Modes of the Enigmatic 5th Histone.Biomolecules · 2026Review
- H1.3 depletion in AML cells prompts H1.2 redistribution, chromatin remodeling and cell cycle defects.Epigenetics & chromatin · 2026Article
- Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells.Science advances · 2026Article
- Hat1 Orchestrates Heterochromatin Inheritance by Regulating Localization of H3K9 Methyltransferases.bioRxiv : the preprint server for biology · 2026Article
- Conformations of Linker Histone H1 Bound to Nucleosome Arrays.Journal of molecular biology · 2026Article
- Past, Present and Future of Regenerative Gene Therapy for Ischemic Heart Failure.Journal of cardiovascular translational research · 2026Review
- Linker histones consolidate heterogenous nucleosome fiber contacts by linking together multiple nucleosomes.Nature communications · 2026Article
- Nucleosome spacing across cell types, diseases, and ages.Nucleic acids research · 2026Review
- Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability.Molecular cell · 2026Article
- Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis.The EMBO journal · 2026Article
- T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response.Nature cell biology · 2026Article
- Equine histones are mobilized within equid alphaherpesvirus 1 (EHV1) replication compartments.Journal of virology · 2025Article
- Direct measurement of sub-kilobase chromatin structure reveals that linker histone H1 broadly compacts chromatin, with differential impact amongst epigenetic states.bioRxiv : the preprint server for biology · 2025Article
- Integrated clinical and single-cell profiling of BCMA CAR-T therapy in relapsed/refractory multiple myeloma.Journal of translational medicine · 2025Article
- Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Linker H1 Histone Direct Top-Down Proteoform Analysis.Journal of proteome research · 2025Article
- Article
- Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers.Molecular cell · 2025Article
- PRMT5 activity sustains histone production to maintain genome integrity.bioRxiv : the preprint server for biology · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 6 institutions in 2 countries.
Michael A Willcockson *Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Sean E Healton *Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2506-4185
Cary N Weiss *Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7768-8956
Boris A Bartholdy *Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Yair BotbolDepartment of Pathology, Albert Einstein College of Medicine, New York, NY, USA.
Laxmi N MishraDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-6596-9651
Dhruv S SidhwaniDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Tommy J WilsonDepartment of Neurology, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
Hugo B PintoDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-6970-4693
Maxim I MaronDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7809-5888
Karin A SkalinaDepartment of Pathology, Albert Einstein College of Medicine, New York, NY, USA.
Laura Norwood ToroDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Jie ZhaoDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Chul-Hwan LeeDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0643-0100
Harry HouDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Nevin YusufovaCell & Molecular Biology Graduate Program, Weill Cornell Medicine, New York, NY, USA.
Cem MeydanInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Adewola OsunsadeChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6340-8765
Yael DavidChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1696-0025
Ethel CesarmanDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3303-6299
Ari M MelnickDivision of Hematology/Oncology, Department of Medicine, Biochemistry, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8074-2287
Simone SidoliDepartment of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, PA, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, PA, USA.
Winfried EdelmannDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Fernando MacianDepartment of Pathology, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2666-035X
Arthur I SkoultchiDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA. arthur.skoultchi@einsteinmed.org.ORCID http://orcid.org/0000-0001-5096-8077
Albert Einstein College of Medicine · USCornell University · USMemorial Sloan Kettering Cancer Center · USHoward Hughes Medical Institute · USNewYork–Presbyterian Hospital · USTranslational Therapeutics (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MWORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2015 to 2024
$17.6MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MRole of novel onco-histone mutations in B-cell malignanciesR01CA234561 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CESARMAN, ETHEL · 2019 to 2023
$3.3MInvestigating histone glycation as a new dynamic epigenetic markR35GM138386 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI DAVID-SHTERNBERG, YAEL E · 2020 to 2024
$2.2MFunctions of Mammalian H1 Linker Histones in Gene Regulation and Chromatin ActivityR01GM147165 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SKOULTCHI, ARTHUR I · 2022 to 2025
$2.1MUse of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell toleranceR01CA226861 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUHA, CHANDAN, MACIAN, FERNANDO · 2018 to 2022
$1.9MFunctions of Mammalian H1 Linker Histones in Gene Regulation and DevelopmentR01GM116143 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SKOULTCHI, ARTHUR I · 2015 to 2018
$1.9MRegulation of Nuclear Functions by Drosophila Linker Histone H1R01GM129244 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FYODOROV, DMITRY V, SKOULTCHI, ARTHUR I · 2018 to 2021
$1.5MNCI NIH HHS F30 CA210539NCI NIH HHS P01 CA196539NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA013330NCI NIH HHS R01 CA226861NCI NIH HHS R01 CA234561NIAID NIH HHS R01 AI118891NIDDK NIH HHS F30 DK107182NIDDK NIH HHS F30 DK108532NIGMS NIH HHS R01 GM116143NIGMS NIH HHS R01 GM147165NIGMS NIH HHS R35 GM138386NIGMS NIH HHS T32 GM007288NIH HHS AI118891NIH HHS GM110104
Abstract
H1 linker histones are the most abundant chromatin-binding proteins
Indexed as
Chromatin Assembly and DisassemblyEpigenesis, GeneticAnimalsCD8-Positive T-LymphocytesCell DifferentiationChromatinEnhancer of Zeste Homolog 2 ProteinFemaleGene SilencingHistonesLymphocyte ActivationMaleMethylationMiceMice, KnockoutChromatinEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.