ArticleScientific reports2020
Large-scale resculpting of cortical circuits in children after surgical resection.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection.iScience · 2024Article
- Hemispheric functional organization, as revealed by naturalistic neuroimaging, in pediatric epilepsy patients with cortical resections.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional Resilience of the Neural Visual Recognition System Post-Pediatric Occipitotemporal Resection.bioRxiv : the preprint server for biology · 2024Article
- With childhood hemispherectomy, one hemisphere can support-but is suboptimal for-word and face recognition.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.