Evidence map›Paper›PMID 33298955›Full record

ArticleNPJ Parkinson's disease2020

A blinded, controlled trial of objective measurement in Parkinson's disease.

Holly Woodrow, Malcolm K Horne, Chathurini V Fernando, Katya E Kotschet, Treat to Target Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  12. Parkinson's disease therapy: what lies ahead?Journal of neural transmission (Vienna, Austria : 1996) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 11 institutions in 1 country.

Holly WoodrowFlorey Institute of Neuroscience and Mental Health Parkville, Melbourne, VIC, 3010, Australia.
Malcolm K HorneFlorey Institute of Neuroscience and Mental Health Parkville, Melbourne, VIC, 3010, Australia. malcolm.horne@florey.edu.au.ORCID http://orcid.org/0000-0001-9427-2100
Chathurini V FernandoFlorey Institute of Neuroscience and Mental Health Parkville, Melbourne, VIC, 3010, Australia.
Katya E KotschetSt Vincent's Hospital Melbourne Fitzroy, Melbourne, VIC, 3065, Australia.
Treat to Target Study Group
The Royal Melbourne Hospital · AURoyal Adelaide Hospital · AUGoulburn Valley Health · AUPrincess Alexandra Hospital · AUSt Vincent's Hospital Melbourne · AUThe University of Melbourne · AUWestmead Hospital · AUFlorey Institute of Neuroscience and Mental Health · AUSt Vincent's Hospital Sydney · AUThe University of Sydney · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson's disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson's disease was improved when clinical assessment and therapeutic decisions were aided by objective measurement. The primary endpoint was improvement in the Movement Disorder Society-United Parkinson's Disease Rating Scale's (MDS-UPDRS) Total Score. In one arm, objective measurement assisted doctors to alter therapy over successive visits until objective measurement scores were in target. Patients in the other arm were conventionally assessed and therapies were changed until judged optimal. There were 75 subjects in the objective measurement arm and 79 in the arm with conventional assessment and treatment. There were statistically significant improvements in the moderate clinically meaningful range in the MDS-UPDRS Total, III, IV scales in the arm using objective measurement, but not in the conventionally treated arm. These findings show that global motor and non-motor disability is improved when management of Parkinson's disease is assisted by objective measurement.

Identifiers

PMID33298955
PMCPMC7680151
OpenAlexW3109532784

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.