Evidence map›Paper›PMID 33298941›Full record

ArticleNPJ Parkinson's disease2020

Cerebrospinal fluid glutamate changes in functional movement disorders.

Benedetta Demartini, Roberto William Invernizzi, Laura Campiglio, Tommaso Bocci, Andrea D'Arrigo, Andrea Arighi, Francesca Sciacca, Daniela Galimberti, Elio Scarpini, Orsola Gambini and 1 more

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Benedetta DemartiniDipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.ORCID http://orcid.org/0000-0003-4426-6014
Roberto William InvernizziLaboratorio Neurochimica e Comportamento, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, Milano, Italy.
Laura CampiglioUnità di Psichiatria II, A.O. San Paolo, ASST Santi Paolo e Carlo, Milano, Italy.
Tommaso BocciDipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
Andrea D'ArrigoDipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
Andrea ArighiUOSD Neurologia, Malattie Neurodegenerative, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID http://orcid.org/0000-0003-2865-3970
Francesca SciaccaDipartimento Biochimica Specialistica Neurologica e Neurofarmacologia, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Daniela GalimbertiUOSD Neurologia, Malattie Neurodegenerative, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID http://orcid.org/0000-0002-9284-5953
Elio ScarpiniUOSD Neurologia, Malattie Neurodegenerative, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Orsola GambiniDipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
Alberto PrioriDipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy. alberto.priori@unimi.it.ORCID http://orcid.org/0000-0002-1549-3851
University of Milan · ITAOL (United States) · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITMario Negri Institute for Pharmacological Research · ITOspedale San Paolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.

Identifiers

PMID33298941
PMCPMC7718900
OpenAlexW3112805926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.