Evidence map›Paper›PMID 33298936›Full record

ReviewNPJ Regenerative medicine2020

Stem cell preservation for regenerative therapies: ethical and governance considerations for the health care sector.

Zubin Master, Aidan P Crowley, Cambray Smith, Dennis Wigle, Andre Terzic, Richard R Sharp

Abstract readReview
In one paragraph

Review in NPJ Regenerative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The impact of initial cooling rates on cell preservation in frozen water-dimethyl sulfoxide media: a morphological study.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Regenerative medicine clinical readiness.Regenerative medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zubin MasterBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, 55905, USA. Master.Zubin@mayo.edu.ORCID http://orcid.org/0000-0002-3462-4546
Aidan P CrowleyCollege of Science, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA.ORCID http://orcid.org/0000-0002-4606-5622
Cambray SmithBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0001-9723-891X
Dennis WigleCenter for Regenerative Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Andre TerzicCenter for Regenerative Medicine, Mayo Clinic, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0001-9210-009X
Richard R SharpBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, 55905, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stem cell preservation industry has grown substantially with private businesses, public hospitals, and academic medical centers considering preserving induced pluripotent stem cells, mesenchymal stem cells, and other cell types of patients and the public in order to potentially use them for stem cell therapy should such an intervention exist in the future. Despite this growth and interest among private firms and academic centers, no study has yet considered the bioethical issues of such platforms. In this article, we explore several ethical and social issues related to the biopreservation of stem cells for future regenerative therapies. We analyze a range of bioethical considerations that public and private institutions should bear in mind as they develop stem cell preservation platforms. These include medical validation of regenerative interventions and their influence on the public understanding of stem cell therapies, the impact of public trust of organizations creating a private, for-profit venture of stem cell preservation, and logistical issues in the governance of the collection including ownership and dispositional authority, informed consent and access, and withdrawal and non-payment. These considerations should be incorporated into current and future stem cell preservation platforms in order to promote the responsible translation of regenerative medicine.

Identifiers

PMID33298936
PMCPMC7708480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.