Evidence map›Paper›PMID 33298867›Full record

ReviewBone research2020

Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies.

Ker Rui Wong, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald, Rhys D Brady

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  14. A Focal Ophthalmic Lesion in a New Zealand White Rabbit (Oryctolagus cuniculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  15. Deciphering the Regulatory Networks of the Migrasome-Associated Cell Subpopulation in Heterotopic Ossification via Multi-Omics Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ker Rui WongDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-7874-0672
Richelle MychasiukDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Sandy R ShultzDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Stuart J McDonaldDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Rhys D BradyDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. rhys.brady@monash.edu.
The Royal Melbourne Hospital · AUMonash University · AULa Trobe University · AU

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NINDS RFA-NS-16-012
6 · The paper itself

Abstract

Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or spinal cord. This abnormal formation of bone can result in nerve impingement, pain, contractures and impaired movement. Patients are often diagnosed with NHO after the bone tissue has completely mineralised, leaving invasive surgical resection the only remaining treatment option. Surgical resection of NHO creates potential for added complications, particularly in patients with concomitant injury to the central nervous system (CNS). Although recent work has begun to shed light on the physiological mechanisms involved in NHO, there remains a significant knowledge gap related to the prognostic biomarkers and prophylactic treatments which are necessary to prevent NHO and optimise patient outcomes. This article reviews the current understanding pertaining to NHO epidemiology, pathobiology, biomarkers and treatment options. In particular, we focus on how concomitant CNS injury may drive ectopic bone formation and discuss considerations for treating polytrauma patients with NHO. We conclude that understanding of the pathogenesis of NHO is rapidly advancing, and as such, there is the strong potential for future research to unearth methods capable of identifying patients likely to develop NHO, and targeted treatments to prevent its manifestation.

Identifiers

PMID33298867
PMCPMC7725771
OpenAlexW3113216470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.