ArticleLight, science & applications2020
Superchiral near fields detect virus structure.
Article in Light, science & applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Near-Field Topology-Optimized Superchiral Metasurfaces for Enhanced Chiral Sensing.Nano letters · 2026Article
- Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum.Nanophotonics (Berlin, Germany) · 2025Article
- Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism.Light, science & applications · 2023Article
- Near-Field Probing of Optical Superchirality with Plasmonic Circularly Polarized Luminescence for Enhanced Bio-Detection.ACS photonics · 2022Article
- Local versus bulk circular dichroism enhancement by achiral all-dielectric nanoresonators.Nanophotonics (Berlin, Germany) · 2022Article
- Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Optical spectroscopy can be used to quickly characterise the structural properties of individual molecules. However, it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component molecules. This insensitivity arises from the mismatch in length scales between the assemblies (a few tens of nm) and the wavelength of light required to excite chromophores (≥150 nm). Consequently, with conventional spectroscopy, ordered assemblies, such as the icosahedral capsids of viruses, appear to be indistinguishable isotropic spherical objects. This limits potential routes to rapid high-throughput portable detection appropriate for point-of-care diagnostics. Here, we demonstrate that chiral electromagnetic (EM) near fields, which have both enhanced chiral asymmetry (referred to as superchirality) and subwavelength spatial localisation (∼10 nm), can detect the icosahedral structure of virus capsids. Thus, they can detect both the presence and relative orientation of a bound virus capsid. To illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields, we have used them to successfully detect virus particles in the complex milieu of blood serum.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.