ArticleMedical science monitor : international medical journal of experimental and clinical research2020
The Prognosis of Preterm Infants Born at the Threshold of Viability: Fog Over the Gray Zone - Population-Based Studies of Extremely Preterm Infants.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- From "can we treat?" to "should we treat?": a narrative review on resuscitation limits at the threshold of viability.European journal of pediatrics · 2026Review
- Physical growth and neurodevelopmental indicators at corrected 6 months of age in preterm infants born at 22-32 weeks gestation: a single-center study.BMC pediatrics · 2025Article
- A Preterm Infant With Gestational Age of 21Clinical case reports · 2025Article
- Lessons From the Survival of an Extremely Preterm Neonate Despite Challenges in a Country Where Gestational Age of Viability Is 28 Weeks.Clinical case reports · 2025Article
- Outcomes and Morbidities in Low-Birth-Weight Neonates: A Retrospective Study From Western India.Cureus · 2024Article
- Withdrawal and withholding of life sustaining treatment (WWLST): an under recognised factor in the morbidity or mortality of periviable infants?-a narrative review.Translational pediatrics · 2024Review
- L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats.Pediatric research · 2023Article
- Cancer and Pregnancy in the Post-Roe v. Wade Era: A Comprehensive Review.Current oncology (Toronto, Ont.) · 2023Review
- The Most Valuable Predictive Factors for Bronchopulmonary Dysplasia in Very Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Analysis of serum metabolism in premature infants before and after feeding using GC-MS and the relationship with necrotizing enterocolitis.Biomedical chromatography : BMC · 2023Article
- National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Maternal HPV Infection: Effects on Pregnancy Outcome.Viruses · 2021Review
- Obstetric and Perinatal Outcomes after Very Early Preterm Premature Rupture of Membranes (PPROM)-A Retrospective Analysis over the Period 2000-2020.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limit of viability for premature newborns has changed in recent decades, but whether to initiate or withhold active care for periviable infants remains a subject of debate because the chances of survival and the extent of severe neurological impairment can be unclear. In our review, we analyzed large population-based studies of periviable infants from the past 2 decades. We compared survival rates and the incidence of early complications among survivors, including bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, and necrotizing enterocolitis. Moreover, we assessed the perinatal factors that may affect the survival of preterm infants. We analyzed 15 studies reporting data on preterm infants born between 22 and 28 gestational weeks. None of these studies reported survival of an infant born before 22 gestational weeks. Survival rates of infants born at 24 weeks' gestation were above 50% in most studies. The incidence of each complication was also higher among infants born at ≤24 weeks. Of the analyzed perinatal factors, antenatal corticosteroid therapy, birth weight, female sex, cesarean delivery, singleton pregnancy, and birth in a tertiary-level Neonatal Intensive Care Unit were found to be associated with improved survival in some studies. The different methodologies of the studies limited comparison of the results. Further investigations are needed to gain up-to-date information on the limit of viability, and standardized methods in future studies would enable more accurate comparisons of findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.