ArticleThorax2021
Frailty subtypes and recovery in older survivors of acute respiratory failure: a pilot study.
Article in Thorax, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Impact of Frailty on Activities of Daily Living in Hospitalized Older Adults: A Systematic Review and Meta-Analysis.Geriatrics & gerontology international · 2026Pooled it
- Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies.Annals of intensive care · 2025Review
- Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study.BMC geriatrics · 2024Article
- Association of metabolic syndrome and frailty with postoperative complications in older gastric cancer patients: A body composition perspective.Cancer medicine · 2024Observational
- Outcome Measures to Evaluate Functional Recovery in Survivors of Respiratory Failure: A Scoping Review.CHEST critical care · 2024Article
- Lower body mass index is an independent predictor of mortality in older patients with acute respiratory distress syndrome.Heliyon · 2024Article
- Identifying Comorbid Subtypes of Patients With Acute Respiratory Failure.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2023Article
- Long-term recovery after critical illness in older adults.Current opinion in critical care · 2022Review
- The clinical impact of frailty on the postoperative outcomes of patients undergoing appendectomy: propensity score-matched analysis of 2011-2017 US hospitals.Aging clinical and experimental research · 2022Article
- Individualized Mechanical power-based ventilation strategy for acute respiratory failure formalized by finite mixture modeling and dynamic treatment regimen.EClinicalMedicine · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIdentifying subtypes of acute respiratory failure survivors may facilitate patient selection for post-intensive care unit (ICU) follow-up clinics and trials.
methodsWe conducted a single-centre prospective cohort study of 185 acute respiratory failure survivors, aged ≥ 65 years. We applied latent class modelling to identify frailty subtypes using frailty phenotype and cognitive impairment measurements made during the week before hospital discharge. We used Fine-Gray competing risks survival regression to test associations between frailty subtypes and recovery, defined as returning to a basic Activities of Daily Living disability count less than or equal to the pre-hospitalisation count within 6 months. We characterised subtypes by pre-ICU frailty (Clinical Frailty Scale score ≥ 5), the post-ICU frailty phenotype, and serum inflammatory cytokines, hormones and exosome proteomics during the week before hospital discharge.
resultsWe identified five frailty subtypes. The recovery rate decreased 49% across each subtype independent of age, sex, pre-existing disability, comorbidity and Acute Physiology and Chronic Health Evaluation II score (recovery rate ratio: 0.51, 95% CI 0.41 to 0.63). Post-ICU frailty phenotype prevalence increased across subtypes, but pre-ICU frailty prevalence did not. In the subtype with the slowest recovery, all had cognitive impairment. The three subtypes with the slowest recovery had higher interleukin-6 levels (p=0.03) and a higher prevalence of ≥ 2 deficiencies in insulin growth factor-1, dehydroepiandrostersone-sulfate, or free-testosterone (p=0.02). Exosome proteomics revealed impaired innate immunity in subtypes with slower recovery.
conclusionsFrailty subtypes varied by prehospitalisation frailty and cognitive impairment at hospital discharge. Subtypes with the slowest recovery were similarly characterised by greater systemic inflammation and more anabolic hormone deficiencies at hospital discharge.
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