Evidence map›Paper›PMID 33298564›Full record

ArticleScience translational medicine2020

Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs.

Shriya S Srinivasan, Greta Tuckute, Jasmine Zou, Samantha Gutierrez-Arango, Hyungeun Song, Robert L Barry, Hugh M Herr

Abstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Using EMG Biofeedback to Restore Closed-Loop Neural Control on a Powered Prosthetic Ankle.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Agonist-antagonist Myoneural Interface.Techniques in orthopaedics (Rockville, Md.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shriya S SrinivasanHarvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. robert.barry@mgh.harvard.edu hherr@media.mit.edu.ORCID 0000-0002-2508-1324
Greta TuckuteMIT Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5572-5469
Jasmine ZouMIT Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Samantha Gutierrez-ArangoMIT Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-6734-1668
Hyungeun SongHarvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-7079-8818
Robert L BarryHarvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. robert.barry@mgh.harvard.edu hherr@media.mit.edu.ORCID 0000-0001-6271-9414
Hugh M HerrMIT Center for Extreme Bionics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. robert.barry@mgh.harvard.edu hherr@media.mit.edu.ORCID 0000-0003-3169-1011

Funding

Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUCE R ROSEN · 2020 to 2026
$10.9M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Spinal cord functional connectivity as a biomarker of spinal cord dysfunctionR01EB027779 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BARRY, ROBERT L · 2019 to 2022
$2.7M
Functional Imaging and resting state connectivity in human spinal cord at 7 TeslaR00EB016689 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BARRY, ROBERT L · 2016 to 2018
$747k
NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R00 EB016689NIBIB NIH HHS R01 EB027779
6 · The paper itself

Abstract

The brain undergoes marked changes in function and functional connectivity after limb amputation. The agonist-antagonist myoneural interface (AMI) amputation is a procedure that restores physiological agonist-antagonist muscle relationships responsible for proprioceptive sensory feedback to enable greater motor control. We compared results from the functional neuroimaging of individuals (

Indexed as

Amputation, SurgicalProprioceptionFeedback, SensoryFunctional NeuroimagingHumansLower Extremity

Identifiers

PMID33298564
PMCPMC7786239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.