ArticleJournal of neurointerventional surgery2021
Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition.
Article in Journal of neurointerventional surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Shell Versus Core Architecture and Biology of Thrombi in Acute Ischemic Stroke: A Systematic Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Histopathological Analysis of Thrombi in Acute Ischemic Stroke: An Exploratory Study of Thrombus Composition and CD34-Positive Endothelial Cells.Diagnostics (Basel, Switzerland) · 2026Article
- Clot Composition Profiling in Large Vessel Occlusion Stroke Via Radiomics.Annals of neurology · 2026Article
- Electrical impedance spectroscopy signatures of red blood cells and platelets in acute ischemic stroke clots in the Clotbase International Registry: Significance for etiology and first pass effect.Journal of neurointerventional surgery · 2026Article
- Endovascular Treatment in Subtypes of Posterior Large Vessel Occlusion: A Pooled Analysis From 2 Registries.Stroke (Hoboken, N.J.) · 2026Article
- Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial.Therapeutic advances in neurological disorders · 2026Article
- The use of the NeVa stent-retriever for bail-out mechanical thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Predicting Stroke Etiology with Radiomics: A Retrospective Study.Medical sciences (Basel, Switzerland) · 2025Article
- Impact of next-generation delivery assist catheters and crossing strategy on reperfusion success in aspiration thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- NIMBUS geometric clot extractor for challenging clots: Real-world clinical experience and clot composition.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management.Journal of thrombosis and thrombolysis · 2025Review
- Sex-Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke-Analyses From the German Stroke Registry-Endovascular Treatment.European journal of neurology · 2025Observational
- Clot signature in patients with large vessel occlusion stroke and concomitant active cancer.European journal of neurology · 2025Article
- Histological analysis of thrombus composition in acute ischemic stroke with large vessel occlusion: impact of r-tPA treatment.Frontiers in neuroscience · 2025Article
- Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- First pass results of mechanical thrombectomy with two-drop zone NeVaInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- Current Approaches and Methods to Understand Acute Ischemic Stroke Treatment Using Aspiration Thrombectomy.Cardiovascular engineering and technology · 2024Review
- Susceptibility vessel sign in patients with subacute ischemic stroke.Quantitative imaging in medicine and surgery · 2024Article
- Association between Left Atrial Appendage Morphology and Clot Histology in Patients with Embolic Ischemic Stroke: An Exploratory Study.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundInitial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.
objectiveTo report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.
methodsAs part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.
resultsClot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1-3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.
conclusionLAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.