Evidence map›Paper›PMID 33298454›Full record

ArticleScience advances2020

The Hippo pathway coactivator Yorkie can reprogram cell fates and create compartment-boundary-like interactions at clone margins.

Joanna C D Bairzin, Maya Emmons-Bell, Iswar K Hariharan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Human ERG oncoprotein repressesProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Imaginal Disc Regeneration: Something Old, Something New.Cold Spring Harbor perspectives in biology · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joanna C D BairzinDepartment of Molecular and Cell Biology, 515 Weill Hall, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7628-0684
Maya Emmons-BellDepartment of Molecular and Cell Biology, 515 Weill Hall, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-4904-9097
Iswar K HariharanDepartment of Molecular and Cell Biology, 515 Weill Hall, University of California, Berkeley, Berkeley, CA 94720, USA. ikh@berkeley.edu.ORCID 0000-0001-6505-0744
University of California, Berkeley · US

Funding

Genetic Regulation of Developmental and Regenerative GrowthR35GM122490 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Iswar K. Hariharan · 2017 to 2026
$5.5M
NIGMS NIH HHS R35 GM122490
6 · The paper itself

Abstract

During development, tissue-specific patterns of gene expression are established by transcription factors and then stably maintained via epigenetic mechanisms. Cancer cells often express genes that are inappropriate for that tissue or developmental stage. Here, we show that high activity levels of Yki, the Hippo pathway coactivator that causes overgrowth in

Indexed as

Drosophila ProteinsAnimalsClone CellsDrosophilaGene Expression Regulation, DevelopmentalHedgehog ProteinsHippo Signaling PathwayHomeodomain ProteinsNuclear ProteinsTrans-ActivatorsTranscription FactorsWings, Animaldpp protein, DrosophilaDrosophila ProteinsHedgehog ProteinsHomeodomain ProteinsNuclear ProteinsTrans-ActivatorsTranscription FactorsUbx protein, Drosophila

Identifiers

PMID33298454
PMCPMC7725458
OpenAlexW3110990894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.