ArticleScience advances2020
Environmental exposure enhances the internalization of microplastic particles into cells.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed.
- Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing.Nucleus (Austin, Tex.) · 2026Review
- Polystyrene nanoplastics induced toxicity in human endothelial cells via atherogenic and autophagy pathways.Discover nano · 2026Article
- Monodisperse Polymer Optical Microresonators as a Versatile Platform for Protein-Conjugated Biocompatible Optical Probes.ACS omega · 2026Article
- Eco-corona: A new frontier in understanding micro- and nanoplastic-gut interactions.World journal of methodology · 2026Review
- Quantifying Cellular Uptake of NanoplasticsACS omega · 2026Article
- Review
- Eco-Corona of Microplastics in Soil Inhibits Their Role as a Contaminant Vector While Enhancing Their Role as a Microorganism Vector.Environmental science & technology · 2026Article
- Polyvinyl chloride promotes radioresistance in hepatocellular carcinoma by inhibiting radiotherapy-induced CD8⁺ T cell differentiation.Nature communications · 2026Article
- Microplastics inhibit macrophage bioenergetics impairing homeostatic function and immune responsiveness.bioRxiv : the preprint server for biology · 2026Article
- Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review ofFrontiers in toxicology · 2026Review
- Polystyrene microplastics internalization by term placental chorionic villi explants.Placenta · 2026Review
- Micro- and nanoplastics remodel the autophagy-lysosomal axis and mitochondrial function in primary human monocytes.Frontiers in immunology · 2026Article
- Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells.Frontiers in toxicology · 2026Article
- Navigating microplastic-induced stress in plants: adaptations from physiology to gene regulation.Plant molecular biology · 2025Review
- Microbubble-induced erosion releases micro- and nanoplastics into water.Science advances · 2025Article
- Article
- Trapping tiny pollutants: SERS-driven strategies for microplastics and nanoplastics detection.iScience · 2025Review
- Article
- Health impacts of microplastic and nanoplastic exposure.Nature medicine · 2025Review
- Environmental protein corona on nanoplastics altered the responses of skin keratinocytes and fibroblast cells to the particles.Journal of hazardous materials · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastic particles ubiquitously found in the environment are ingested by a huge variety of organisms. Subsequently, microplastic particles can translocate from the gastrointestinal tract into the tissues likely by cellular internalization. The reason for cellular internalization is unknown, since this has only been shown for specifically surface-functionalized particles. We show that environmentally exposed microplastic particles were internalized significantly more often than pristine microplastic particles into macrophages. We identified biomolecules forming an eco-corona on the surface of microplastic particles, suggesting that environmental exposure promotes the cellular internalization of microplastics. Our findings further indicate that cellular internalization is a key route by which microplastic particles translocate into tissues, where they may cause toxicological effects that have implications for the environment and human health.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.