Evidence map›Paper›PMID 33298439›Full record

ArticleScience advances2020

Cryo-shocked cancer cells for targeted drug delivery and vaccination.

Tianyuan Ci, Hongjun Li, Guojun Chen, Zejun Wang, Jinqiang Wang, Peter Abdou, Yiming Tu, Gianpietro Dotti, Zhen Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Oocyte-inspired universal whole-cell vaccines against tumor heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Cryopreservation of biological materials: applications and economic perspectives.In vitro cellular & developmental biology. Animal · 2026
    Review
  9. National science review · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Cryo-Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianyuan CiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2887-3642
Hongjun LiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-1765-8445
Guojun ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zejun WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0313-5819
Jinqiang WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0048-838X
Peter AbdouDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-4195-3903
Yiming TuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Gianpietro DottiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Raleigh, NC 27599, USA.ORCID 0000-0002-2639-8526
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. guzhen@zju.edu.cn.ORCID 0000-0003-2947-4456

Funding

Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA234343
6 · The paper itself

Abstract

Live cells have been vastly engineered into drug delivery vehicles to leverage their targeting capability and cargo release behavior. Here, we describe a simple method to obtain therapeutics-containing "dead cells" by shocking live cancer cells in liquid nitrogen to eliminate pathogenicity while preserving their major structure and chemotaxis toward the lesion site. In an acute myeloid leukemia (AML) mouse model, we demonstrated that the liquid nitrogen-treated AML cells (LNT cells) can augment targeted delivery of doxorubicin (DOX) toward the bone marrow. Moreover, LNT cells serve as a cancer vaccine and promote antitumor immune responses that prolong the survival of tumor-bearing mice. Preimmunization with LNT cells along with an adjuvant also protected healthy mice from AML cell challenge.

Indexed as

Drug Delivery SystemsLeukemia, Myeloid, AcuteAnimalsCell Line, TumorDoxorubicinMiceNitrogenVaccinationDoxorubicinNitrogen

Identifiers

PMID33298439
PMCPMC7725453

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.