Evidence map›Paper›PMID 33297844›Full record

ArticleJournal of neurotrauma2021

Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases.

Michelle C LaPlaca, J Russell Huie, Hasan B Alam, Adam D Bachstetter, Hűlya Bayir, Patrick F Bellgowan, Diana Cummings, C Edward Dixon, Adam R Ferguson, Chantelle Ferland-Beckham and 25 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 2 countries.

Michelle C LaPlacaDepartment of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Georgia, USA.
J Russell HuieBrain and Spinal Injury Center, Department of Neurological Surgery, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Hasan B AlamDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Adam D BachstetterDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Hűlya BayirDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Patrick F BellgowanNational Institutes of Health, Bethesda, Maryland, USA.
Diana CummingsNational Institutes of Health, Bethesda, Maryland, USA.
C Edward DixonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Adam R FergusonBrain and Spinal Injury Center, Department of Neurological Surgery, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Chantelle Ferland-BeckhamCohen Veterans Bioscience, Cambridge, Massachusetts, USA.
Candace L FloydDepartment of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah, USA.
Stuart H FriessDivision of Critical Care Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
Aristea S GalanopoulouDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Edward D HallDepartment of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Neil G HarrisDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, USA.
Bridget E HawkinsDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA.
Ramona R HicksOne Mind, Rutherford, California, USA.
Lindsey E HulbertDepartment of Animal Sciences and Industry, Kansas State University, Manhattan, Kansas, USA.
Victoria E JohnsonDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Patricia A KabitzkeBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Audrey D LafrenayeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Vance P LemmonDepartment of Neurological Surgery, University of Miami, Miami, Florida, USA.
Carrie W LifshitzDepartment of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, Arizona, USA.
Jonathan LifshitzDepartment of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, Arizona, USA.
David J LoaneSchool of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Leonie MisquittaNational Institutes of Health, Bethesda, Maryland, USA.
Vahagn C NikolianDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Linda J Noble-HaeussleinDepartments of Psychology and Neurology, University of Texas at Austin, Austin, Texas, USA.
Douglas H SmithDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Carol Taylor-BurdsNational Institutes of Health, Bethesda, Maryland, USA.
Nsini UmohDepartment of Defense, U.S. Army Medical Research and Materiel Command, Fort Detrick, Frederick, Maryland, USA.
Olga VovkNational Institutes of Health, Bethesda, Maryland, USA.
Aaron M WilliamsDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Margaret YoungDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Laila J ZaiLucent Neuroscience, Parker, Colorado, USA.
National Institutes of Health · USUniversity of Michigan · USUniversity of Pittsburgh · USNeurological Surgery · USUniversity of Arizona · USUniversity of Kentucky · USUniversity of Pennsylvania · USAlbert Einstein College of Medicine · USBroad Institute · USCohen Veterans Bioscience · USGeorgia Institute of Technology · USKansas State University · USOne Mind · USParker Adventist Hospital · USThe University of Texas at Austin · USThe University of Texas Medical Branch at Galveston · USTrinity College Dublin · IEUnited States Army Medical Research and Development Command · USUniversity of California, Los Angeles · USUniversity of Miami · US

Funding

Neuropathological Characterization of 'CTE'R01NS094003 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith, William Stewart · 2016 to 2026
$5.1M
Detection and Mechanisms of Mild Traumatic Brain InjuryR01NS092398 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2015 to 2019
$1.9M
DELAYED HYPOXEMIA FOLLOWING TRAUMATIC BRAIN INJURY: A NEW TARGET FOR NEUROPROTECTIVE THERAPEUTICSR01NS097721 · NINDS · WASHINGTON UNIVERSITY · PI FRIESS, STUART H · 2017 to 2021
$1.7M
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UH3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2020 to 2022
$1.2M
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UG3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2018 to 2019
$480k
Leveraging data-science for discovery in chronic TBII01RX002787 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI FERGUSON, ADAM R · 2018 to 2025
–
NINDS NIH HHS R01 NS092398NINDS NIH HHS R01 NS094003NINDS NIH HHS R01 NS097721NINDS NIH HHS UG3 NS106899NINDS NIH HHS UH3 NS106899RRD VA I01 RX002787
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical and clinical researchers face challenges with reproducibility that negatively impact translation and therapeutic development for improved TBI patient outcomes. To address this challenge, TBI Pre-clinical Working Groups expanded upon previous efforts and developed common data elements (CDEs) to describe the most frequently used experimental parameters. The working groups created 913 CDEs to describe study metadata, animal characteristics, animal history, injury models, and behavioral tests. Use cases applied a set of commonly used CDEs to address and evaluate the degree of missing data resulting from combining legacy data from different laboratories for two different outcome measures (Morris water maze [MWM]; RotorRod/Rotarod). Data were cleaned and harmonized to Form Structures containing the relevant CDEs and subjected to missing value analysis. For the MWM dataset (358 animals from five studies, 44 CDEs), 50% of the CDEs contained at least one missing value, while for the Rotarod dataset (97 animals from three studies, 48 CDEs), over 60% of CDEs contained at least one missing value. Overall, 35% of values were missing across the MWM dataset, and 33% of values were missing for the Rotarod dataset, demonstrating both the feasibility and the challenge of combining legacy datasets using CDEs. The CDEs and the associated forms created here are available to the broader pre-clinical research community to promote consistent and comprehensive data acquisition, as well as to facilitate data sharing and formation of data repositories. In addition to addressing the challenge of standardization in TBI pre-clinical studies, this effort is intended to bring attention to the discrepancies in assessment and outcome metrics among pre-clinical laboratories and ultimately accelerate translation to clinical research.

Indexed as

Brain Injuries, TraumaticDisease Models, AnimalAnimalsCommon Data Elementsbig datacommon data elementsmissing value analysispre-clinicalreproducibility

Identifiers

PMID33297844
PMCPMC8082734
OpenAlexW3113278277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.