Evidence map›Paper›PMID 33297828›Full record

ArticleJournal of neurotrauma2021

Spinal Dopaminergic Mechanisms Regulating the Micturition Reflex in Male Rats with Complete Spinal Cord Injury.

Yuan Qiao, Zachary D Brodnik, Shunyi Zhao, Cameron T Trueblood, Zhenzhong Li, Veronica J Tom, Rodrigo A España, Shaoping Hou

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Upregulated 5-HTJournal of neurotrauma · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yuan QiaoDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Zachary D BrodnikDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Shunyi ZhaoDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Cameron T TruebloodDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Zhenzhong LiDepartment of Anatomy, Shandong University School of Basic Medical Sciences, Ji'nan, China.
Veronica J TomDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Rodrigo A EspañaDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Shaoping HouDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Drexel University · USShandong University · CN

Funding

Multipronged approach to promote functional axonal regeneration in the spinal cord after injuryR01NS085426 · NINDS · DREXEL UNIVERSITY · PI TOM, VERONICA JEAN · 2014 to 2024
$3.6M
Soluble TNFa in the development of autonomic dysreflexia after spinal cord injuryR01NS106908 · NINDS · DREXEL UNIVERSITY · PI BETHEA, JOHN ROLAND, TOM, VERONICA JEAN · 2018 to 2022
$2.9M
Spinal dopaminergic mechanisms regulating the micturition reflex after spinal cord injuryR01NS099076 · NINDS · DREXEL UNIVERSITY · PI HOU, SHAOPING · 2017 to 2021
$1.8M
NINDS NIH HHS R01 NS085426NINDS NIH HHS R01 NS099076NINDS NIH HHS R01 NS106908
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) often causes micturition dysfunction. We recently discovered a low level of spinally-derived dopamine (DA) that regulates recovered bladder and sphincter reflexes in SCI female rats. Considering substantial sexual dimorphic features in the lower urinary tract, it is unknown if the DA-ergic mechanisms act in the male. Histological analysis showed a similar distribution of tyrosine hydroxylase (TH)

Indexed as

AnimalsDopamineDopamine AntagonistsElectromyographyFemaleMaleRatsRats, WistarReceptors, Dopamine D1Receptors, Dopamine D2Spinal Cord InjuriesThoracic VertebraeUrinary BladderUrinationDopamineDopamine AntagonistsReceptors, Dopamine D1Receptors, Dopamine D2bladderexternal urethral sphinctersex differencespontaneous recovery

Identifiers

PMID33297828
PMCPMC8098773
OpenAlexW3112887229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.