Evidence map›Paper›PMID 33297592›Full record

ArticleInternational journal of molecular sciences2020

Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis.

Stefano J Mandriota, Mirna Tenan, Adeline Nicolle, Julia D Jankowska, Paolo Ferrari, Jean-Christophe Tille, Mary-Anne Durin, Catherine M Green, Sebastien Tabruyn, Daniela Moralli and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The MAK collection for occupational health and safety · 2025
    Review
  5. Article
  6. Prosthetic Metals: Release, Metabolism and Toxicity.International journal of nanomedicine · 2024
    Review
  7. Review
  8. Article
  9. Evaluation of twoMolecular therapy. Methods & clinical development · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Stefano J MandriotaLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.
Mirna TenanLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.
Adeline NicolleLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.ORCID 0000-0002-4616-3599
Julia D JankowskaWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Paolo FerrariLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.
Jean-Christophe TilleDepartment of Pathology, Geneva University Hospital, 1205 Geneva, Switzerland.ORCID 0000-0002-2255-5918
Mary-Anne DurinWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0003-4073-3463
Catherine M GreenWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Sebastien TabruynTransCure bioServices, 74160 Archamps, France.ORCID 0000-0002-1917-1729
Daniela MoralliWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0001-7977-8496
André-Pascal SappinoLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.
Hirslanden Clinique des Grangettes · CHCentre for Human Genetics · GBTransCure BioServices (France) · FRUniversity Hospital of Geneva · CH

Funding

Ligue Genevoise Contre le Cancer 1515
6 · The paper itself

Abstract

Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unknown mechanisms. We report here that long-term culture in the presence of aluminium chloride (AlCl

Indexed as

Genomic InstabilityAluminumAnimalsCarcinogenesisCarcinogens, EnvironmentalCell Line, TumorFemaleMiceMice, Inbred BALB CAluminumCarcinogens, Environmentalaluminiumbreast cancercarcinogenesisclastogensgenomic instability

Identifiers

PMID33297592
PMCPMC7730342
OpenAlexW3111226953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.