Evidence map›Paper›PMID 33297490›Full record

ReviewBiomolecules2020

Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator.

Minu Chaudhuri, Chauncey Darden, Fidel Soto Gonzalez, Ujjal K Singha, Linda Quinones, Anuj Tripathi

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Minu ChaudhuriMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Chauncey DardenMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Fidel Soto GonzalezMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Ujjal K SinghaMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Linda QuinonesMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Anuj TripathiMeharry Medical College, Department of Microbiology, Immunology, and Physiology, 1005 Dr. D.B. Todd, Jr., Blvd, Nashville, TN 37208, USA.
Meharry Medical College · US

Funding

THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
MOLECULAR PARASITOLOGY TRAINING PROGRAMT32AI007281 · NIAID · MEHARRY MEDICAL COLLEGE · PI NDE, PIUS N · 1985 to 2025
$3.2M
Understanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7M
Structure and function of the Trypanosome TIM complexR01AI125662 · NIAID · MEHARRY MEDICAL COLLEGE · PI CHAUDHURI, MINU · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI125662NIAID NIH HHS T32 AI007281NIGMS NIH HHS R25 GM059994
6 · The paper itself

Abstract

The translocases of the mitochondrial outer and inner membranes, the TOM and TIMs, import hundreds of nucleus-encoded proteins into mitochondria. TOM and TIMs are multi-subunit protein complexes that work in cooperation with other complexes to import proteins in different sub-mitochondrial destinations. The overall architecture of these protein complexes is conserved among yeast/fungi, animals, and plants. Recent studies have revealed unique characteristics of this machinery, particularly in the eukaryotic supergroup Excavata. Despite multiple differences, homologues of Tim17, an essential component of one of the TIM complexes and a member of the Tim17/Tim22/Tim23 family, have been found in all eukaryotes. Here, we review the structure and function of Tim17 and Tim17-containing protein complexes in different eukaryotes, and then compare them to the single homologue of this protein found in

Indexed as

AnimalsCell NucleusConserved SequenceFungiGene ExpressionHumansMembrane Transport ProteinsMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsMultiprotein ComplexesPlantsProtein BindingProtein Structure, SecondaryMembrane Transport ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsMultiprotein ComplexesTIM22 protein, humanTIMM17A protein, humanTIMM23 protein, humanmitochondriaprotein importTIMTim17TOMtrypanosomes

Identifiers

PMID33297490
PMCPMC7762337
OpenAlexW3111627004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.