Evidence map›Paper›PMID 33297368›Full record

ReviewCells2020

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV.

Maria Anele Romeo, Roberta Santarelli, Maria Saveria Gilardini Montani, Roberta Gonnella, Rossella Benedetti, Alberto Faggioni, Mara Cirone

Abstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria Anele RomeoDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Roberta SantarelliDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Maria Saveria Gilardini MontaniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8722-7539
Roberta GonnellaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4894-4986
Rossella BenedettiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alberto FaggioniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Mara CironeDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-2207-9624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.

Indexed as

AutophagyHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 8, HumanHerpesviridae InfectionsHumansImmune SystemMacrophagesNeoplasmsReactive Oxygen SpeciesVirus DiseasesReactive Oxygen SpeciesADautophagycancerDCsEBVHHV-6KSHVROSUPR

Identifiers

PMID33297368
PMCPMC7762304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.