Evidence map›Paper›PMID 33297360›Full record

ArticleBiomedicines2020

Mutations and Copy Number Alterations in

Ege Ülgen, Sıla Karacan, Umut Gerlevik, Özge Can, Kaya Bilguvar, Yavuz Oktay, Cemaliye B Akyerli, Şirin K Yüksel, Ayça E Danyeli, Tarık Tihan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ege ÜlgenDepartment of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.ORCID 0000-0003-2090-3621
Sıla KaracanDepartment of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.ORCID 0000-0001-6617-1310
Umut GerlevikDepartment of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.ORCID 0000-0003-4288-6340
Özge CanDepartment of Medical Engineering, Faculty of Engineering, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Kaya BilguvarDepartment of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-7313-7652
Yavuz OktayIzmir Biomedicine and Genome Center (IBG), Izmir 35340, Turkey.ORCID 0000-0002-0158-2693
Cemaliye B AkyerliDepartment of Medical Biology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Şirin K YükselDepartment of Medical Biology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Ayça E DanyeliDepartment of Pathology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Tarık TihanNeuropathology Division, Department of Pathology, School of Medicine, University of California San Fransisco (UCSF), San Francisco, CA 94143, USA.
O Uğur SezermanDepartment of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
M Cengiz YakıcıerDepartment of Molecular Biology, School of Arts and Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
M Necmettin PamirDepartment of Neurosurgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Koray ÖzdumanDepartment of Neurosurgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Kent Hastanesi · TRIzmir University · TRUniversity of California, San Francisco · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Little is known about the mutational processes that shape the genetic landscape of gliomas. Numerous mutational processes leave marks on the genome in the form of mutations, copy number alterations, rearrangements or their combinations. To explore gliomagenesis, we hypothesized that gliomas with different underlying oncogenic mechanisms would have differences in the burden of various forms of these genomic alterations. This was an analysis on adult diffuse gliomas, but

Indexed as

DNA repairexome sequencinggliomamutational signatures

Identifiers

PMID33297360
PMCPMC7762325
OpenAlexW3112258428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.