Evidence map›Paper›PMID 33297341›Full record

ArticleVaccines2020

Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP

Srilatha Edupuganti, Stephen C De Rosa, Marnie Elizaga, Yiwen Lu, Xue Han, Yunda Huang, Edith Swann, Laura Polakowski, Spyros A Kalams, Michael Keefer and 16 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 1 country.

Srilatha EdupugantiDivision of Infectious Disease, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Stephen C De RosaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Marnie ElizagaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0003-3515-1530
Yiwen LuVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Xue HanVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Yunda HuangVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Edith SwannDivision of AIDS, NIH, Bethesda, MD 20892, USA.
Laura PolakowskiDivision of AIDS, NIH, Bethesda, MD 20892, USA.
Spyros A KalamsVanderbilt University Medical Center, Nashville, TN 37232, USA.
Michael KeeferDepartment of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642, USA.
Janine MaenzaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Megan C WiseInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Jian YanInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Matthew P MorrowInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Amir S KhanInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Jean D BoyerInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Laurent HumeauInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Scott WhiteInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Niranjan Y SardesaiInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Mark L BagarazziInovio Pharmaceuticals Inc. Plymouth Meeting, PA 19462, USA.
Peter B GilbertVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
James G KublinVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lawrence CoreyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
David B WeinerWistar Institute, Philadelphia, PA 19104, USA.
On Behalf Of The Hvtn Study Team
The Niaid-Funded Hiv Vaccine Trials Network
Inovio Pharmaceuticals (United States) · USFred Hutch Cancer Center · USUniversity of Washington · USOffice of AIDS Research · USEmory University · USThe Wistar Institute · USUniversity of Rochester · USVanderbilt University Medical Center · US

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
Emory HIV/AIDS Clinical Trials UnitUM1AI069418 · NIAID · EMORY UNIVERSITY · PI Moises Arturo Huaman Joo, Colleen F Kelley · 2012 to 2026
$46.0M
Synthetic DNA & Novel Env Vaccine for HIVU19AI109646 · NIAID · WISTAR INSTITUTE · PI WEINER, DAVID B. · 2015 to 2019
$16.7M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
NIAID NIH HHS U19 AI109646NIAID NIH HHS UM1 AI068614NIAID NIH HHS UM1 AI068635NIAID NIH HHS UM1 AI069418NIA NIH HHS U54 AG062334NIH HHS U01 AI069418-08
6 · The paper itself

Abstract

methodsThe HVTN 098 trial assessed the PENNVAX

resultsHVTN 098 enrolled 94 participants: 85 received PENNVAX

conclusionsID/EP and IM/EP are distinct experiences; however, HIV-1 DNA vaccination by either route was safe, tolerable and acceptable by most study participants.

Indexed as

DNA vaccineelectroporationHIV vaccineIL-12intradermalintramuscularsafety

Identifiers

PMID33297341
PMCPMC7762306
OpenAlexW3111112554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.