Evidence map›Paper›PMID 33296680›Full record

ArticleCurrent biology : CB2021

PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo.

Jennie S Campbell, Andrew J Davidson, Henry Todd, Frederico S L M Rodrigues, Abigail M Elliot, Jason J Early, David A Lyons, Yi Feng, Will Wood

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jennie S CampbellCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK; School of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK. Electronic address: j.campbell2@exeter.ac.uk.
Andrew J DavidsonCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK.
Henry ToddCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK.
Frederico S L M RodriguesSchool of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK.
Abigail M ElliotCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK.
Jason J EarlyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
David A LyonsCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Yi FengCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK.
Will WoodCentre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK. Electronic address: w.wood@ed.ac.uk.
University of Edinburgh · GBCentre for Inflammation Research · GBUniversity of Bristol · GB

Funding

Wellcome TrustWellcome Trust 100104/Z/12/ZWellcome Trust 107355/Z/15/ZWellcome Trust 107940/Z/15/ZWellcome Trust 214244/Z/18/Z
6 · The paper itself

Abstract

Drosophila provides a powerful model in which to study inflammation in vivo, and previous studies have revealed many of the key signaling events critical for recruitment of immune cells to tissue damage. In the fly, wounding stimulates the rapid production of hydrogen peroxide (H

Indexed as

Drosophila ProteinsMembrane ProteinsProtein Tyrosine Phosphatases, Non-ReceptorZebrafishAnimalsDrosophilaHydrogen PeroxideInflammationLarvaProtein Tyrosine PhosphatasesProto-Oncogene Proteins pp60(c-src)Drosophila ProteinsHydrogen PeroxideMembrane ProteinsProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorProto-Oncogene Proteins pp60(c-src)Src42A protein, DrosophilaDraperDrosophilainflammationmacrophageMegf10migrationneutrophilPezPTPN21zebrafish

Identifiers

PMID33296680
PMCPMC7902905
OpenAlexW3111420365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.