ArticleCell reports2020
Divergent Nodes of Non-autonomous UPR
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity.Genes & development · 2026Article
- Heat stress reveals bidirectional cross talk between the heat shock response and UPRER in C. elegans.G3 (Bethesda, Md.) · 2026Article
- The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.Nature neuroscience · 2026Article
- Adaptive inter-tissue proteostasis networks in aging and neurodegeneration.Bioscience reports · 2026Review
- Exploring non-autonomous protein homeostasis driven by glutamatergic neurons.microPublication biology · 2026Article
- Distinct responses to non-autonomous UPRCommunications biology · 2025Article
- From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging.Biogerontology · 2025Review
- Homeostasis control in health and disease by the unfolded protein response.Nature reviews. Molecular cell biology · 2025Review
- Essential roles of the unfolded protein response in intestinal physiology.eGastroenterology · 2024Review
- Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease.Pharmacological research · 2024Review
- Article
- Mechanical stress through growth on stiffer substrates impacts animal health and longevity inbioRxiv : the preprint server for biology · 2024Article
- Glial-derived mitochondrial signals affect neuronal proteostasis and aging.Science advances · 2023Article
- Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans.PLoS biology · 2023Article
- Article
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.EMBO reports · 2023Article
- Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.Nature cell biology · 2023Article
- Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.Aging cell · 2023Article
- Glia ofScience advances · 2022Article
- Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Ryo Higuchi-SanabriaDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Jenni DurieuxDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Naame KeletDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Stefan HomentcovschiDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Mattias de Los Rios RogersDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Samira MonshietehadiDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Gilberto GarciaDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Sofia DallardaDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Joseph R DanieleTRACTION, The University of Texas MD Anderson Cancer Center, South Campus Research, Houston, TX 77054, USA.
Vidhya RamachandranDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Arushi SahayDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Sarah U TronnesDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80309, USA.
Larry JoeDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.
Andrew DillinDepartment of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.
Howard Hughes Medical Institute · USUniversity of California, Berkeley · USThe University of Texas MD Anderson Cancer Center · USUniversity of Colorado Boulder · US
Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MCell non-autonomous function of the unfolded protein responseR01AG042679 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2013 to 2017
$1.5MMore than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747kMore than just a load control: cytoskeletal form and function during agingK99AG065200 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2020 to 2021
$244kHoward Hughes Medical InstituteNIA NIH HHS K99 AG065200NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG042679NIH HHS P40 OD010440
Abstract
In multicellular organisms, neurons integrate a diverse array of external cues to affect downstream changes in organismal health. Specifically, activation of the endoplasmic reticulum (ER) unfolded protein response (UPR
Indexed as
AgingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDopaminergic NeuronsEndoplasmic ReticulumEndoplasmic Reticulum StressLipid MetabolismLongevityNeuronsProteostasisSerotonergic NeuronsSignal TransductionUnfolded Protein ResponseCaenorhabditis elegans Proteinsagingnon-autonomous signalingstress responseUPRER
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.