Evidence map›Paper›PMID 33296646›Full record

ArticleCell reports2020

Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex.

Anna M Van Keuren, Chen-Wei Tsai, Enrique Balderas, Madison X Rodriguez, Dipayan Chaudhuri, Ming-Feng Tsai

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  6. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
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  19. Review
  20. IGF-1 boosts mitochondrial function by a CaFrontiers in physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anna M Van KeurenDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Chen-Wei TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Enrique BalderasNora Eccles Harrison Cardiovascular Research and Training Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Madison X RodriguezDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Ming-Feng TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ming-feng.tsai@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USUniversity of Utah · US

Funding

Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3M
Molecular mechanisms of the mitochondrial calcium uniporterR01GM129345 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TSAI, MING-FENG · 2018 to 2022
$1.6M
NHLBI NIH HHS R01 HL141353NIGMS NIH HHS R01 GM129345
6 · The paper itself

Abstract

The mitochondrial calcium uniporter is a multi-subunit Ca

Indexed as

CalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsHEK293 CellsHumansMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsMICU1 protein, humanmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinsSMDT1 protein, humancalcium channelscalcium signalingmembrane transportmitochondrial calcium

Identifiers

PMID33296646
PMCPMC7764451
OpenAlexW3112557658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.