Evidence map›Paper›PMID 33296605›Full record

ArticleThe Journal of international medical research2020

Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway.

Jie Pan, Zongbin Xu, Meifang Xu, Xiaoyan Lin, Bingqiang Lin, Mengxin Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jie PanDepartment of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.
Zongbin XuDepartment of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.
Meifang XuDepartment of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.
Xiaoyan LinDepartment of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.
Bingqiang LinDepartment of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.
Mengxin LinDepartment of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.ORCID https://orcid.org/0000-0001-5462-540X
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the role and the underlying mechanisms of Forkhead box A1 (encoded by

methodsWe analyzed

resultsFOXA1 immunostaining was higher in colon cancer tissues than adjacent healthy tissues.

conclusion

Indexed as

Colonic NeoplasmsHepatocyte Nuclear Factor 3-alphaProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseApoptosisCarcinogenesisCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansPhosphoric Monoester HydrolasesFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanColon cancerForkhead box A1invasionmigrationphosphatase and tensin homolog/Akt signaling pathwayproliferation

Identifiers

PMID33296605
PMCPMC7731712
OpenAlexW3111008727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.