ReviewAmerican journal of physiology. Cell physiology2021
Molecular nature and physiological role of the mitochondrial calcium uniporter channel.
Open access · greenAbstract readReview
In one paragraph
Review in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 150 citations in OpenAlex.
- Veh1 modulates CaaBIOTECH · 2026Article
- Integrated Bioinformatics and Experimental Validation Reveal the Diagnostic and Prognostic Value of SMDT1 in Thyroid Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Cannabidiol alleviates traumatic brain injury-induced neuronal damage and cognitive deficits by inhibiting ferroptosis via the TRPV1/MCU/PI3K/Akt pathway.Cellular & molecular biology letters · 2026Article
- The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026Review
- Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female Mice.Muscles (Basel, Switzerland) · 2026Article
- SIRT1 regulates CaOx crystal-induced exacerbation of renal mitochondrial dysfunction and fibrosis through PPAR-α in aged mice.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Mitochondrial CaCommunications biology · 2026Article
- The pivotal role of mitochondria in the pathogenesis and treatment of liver failure: a comprehensive review.Molecular and cellular biochemistry · 2026Review
- Mcu regulates bone formation via mitochondrial calcium uptake and lineage allocation.Experimental & molecular medicine · 2026Article
- Advances in understanding mitophagy's role in lung injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Review
- Copper (CuPharmaceuticals (Basel, Switzerland) · 2026Article
- DKK1/SMDT1 participate in Ang II-induced mitochondrial injury of human smooth muscle cells in an abdominal aortic aneurysm cell model.Experimental and therapeutic medicine · 2026Article
- Alteration of Mitochondrial Ca2+ Fluxes by Kaempferol and CGP-37157 Regulates Ca2+ Oscillations in Human Alveolar Type 2 A549 Cells.Physiological research · 2026Article
- Advances in Elucidating the Mitochondrial DNA Mechanisms Underlying Ozone-Induced Inflammation.Toxics · 2026Review
- Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Reviews in cardiovascular medicine · 2026Review
- Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities.Trends in pharmacological sciences · 2026Review
- Synaptic mitochondrial dysfunction and Alzheimer's disease: from molecular mechanisms to therapeutic strategies.Frontiers in pharmacology · 2026Review
- The hierarchical stratum response system of organism to microgravity during spaceflight.Military Medical Research · 2026Review
- Integration of transcriptome and Mendelian randomization analyses in exploring the extracellular vesicle-related biomarkers of diabetic kidney disease.Renal failure · 2025Article
- Impaired cardiac non-neuronal acetylcholine synthesis triggers mitochondrial dysfunction with the loss of nicotinic receptor-mediated calcium handling, causing the failing heart.Clinical science (London, England : 1979) · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors at 4 institutions in 2 countries.
B Rita AlevriadouDepartment of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences and School of Engineering and Applied Sciences, University at Buffalo-State University of New York, Buffalo, New York.ORCID 0000-0003-1897-755X
Akshar PatelDepartment of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences and School of Engineering and Applied Sciences, University at Buffalo-State University of New York, Buffalo, New York.
Megan NobleDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Sagnika GhoshDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas.ORCID 0000-0003-2883-7008
Vishal M GohilDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas.ORCID 0000-0002-9920-2563
Peter B StathopulosDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Muniswamy MadeshDepartment of Medicine/Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Texas A&M University · USUniversity at Buffalo, State University of New York · USWestern University · CAThe University of Texas Health Science Center at San Antonio · US
Funding
Coordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MMolecular Mechanisms of Copper Delivery to Mitochondrial Cytochrome c OxidaseR01GM111672 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI GOHIL, VISHAL MAHENDRASINGH · 2014 to 2022
$2.8MControl of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0MEssential Role for SPG7 in Mitochondrial Permeability Transition Pore Assembly and FunctionR01GM135760 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2020 to 2021
$613kMultiphoton Confocal Microscopy for Biomedical ResearchS10RR027327 · NCRR · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2010 to 2010
$500kNCRR NIH HHS S10 RR027327NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL142673NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM111672NIGMS NIH HHS R01 GM135760
Abstract
Calcium (Ca
Indexed as
Calcium SignalingEnergy MetabolismAnimalsApoptosisCalcium ChannelsCardiovascular DiseasesGene Expression RegulationHumansMembrane Potential, MitochondrialMitochondriaMitochondrial DiseasesMolecular Targeted TherapyMuscular DiseasesNeurodegenerative DiseasesProtein ConformationReactive Oxygen SpeciesCalcium Channelsmitochondrial calcium uniporterReactive Oxygen Speciescalcium signalingmitochondrial calcium uptakemitochondrial energeticsreactive oxygen species
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.