Evidence map›Paper›PMID 33296250›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure.

Jesus D Melgarejo, Wen-Yi Yang, Lutgarde Thijs, Yan Li, Kei Asayama, Tine W Hansen, Fang-Fei Wei, Masahiro Kikuya, Takayoshi Ohkubo, Eamon Dolan and 22 more

Open access · hybridAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Characterization of theMolecules (Basel, Switzerland) · 2024
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  5. Postpartum anthropometric and cardiovascular profile following hypertensive disorders of pregnancy: 12-month follow-up.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
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  12. Article
  13. Article
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  16. Optimal Calculation of Mean Pressure From Pulse Pressure.American journal of hypertension · 2023
    Article
  17. Article
  18. What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 16 institutions in 13 countries.

Jesus D MelgarejoFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
Wen-Yi YangFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
Lutgarde ThijsFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
Yan LiCenter for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Y.L., Q.-F.H., J.-G.W.).
Kei AsayamaDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., M.K., T.O.).
Tine W HansenSteno Diabetes Center Copenhagen, Gentofte and Research Centre for Prevention and Health, Capital Region of Denmark (T.W.H.).
Fang-Fei WeiFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
Masahiro KikuyaDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., M.K., T.O.).
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., M.K., T.O.).
Eamon DolanStroke and Hypertension Unit, Blanchardstown, Dublin, Ireland (E.D.).
Katarzyna Stolarz-SkrzypekFirst Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland (K.S.-S., K.K.-J.).
Qi-Fang HuangCenter for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Y.L., Q.-F.H., J.-G.W.).
Valérie TikhonoffDepartment of Medicine, University of Padova, Italy (V.T., E.C.).
Sofia MalyutinaInstitute of Internal and Preventive Medicine, Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russian Federation (S.M.).
Edoardo CasigliaDepartment of Medicine, University of Padova, Italy (V.T., E.C.).
Lars LindSection of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Sweden (L.L.).
Edgardo SandoyaAsociación Española Primera de Socorros Mutuos, Montevideo, Uruguay (E.S.).
Jan FilipovskýFaculty of Medicine, Charles University, Pilsen, Czech Republic (J.F.).
Natasza Gilis-MalinowskaDepartment of Hypertension, Medical University of Gdańsk, Poland (N.G.-M., K.N.).
Krzysztof NarkiewiczDepartment of Hypertension, Medical University of Gdańsk, Poland (N.G.-M., K.N.).
Kalina Kawecka-JaszczFirst Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland (K.S.-S., K.K.-J.).
José BoggiaCentro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.B.).
Ji-Guang WangCenter for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Y.L., Q.-F.H., J.-G.W.).
Yutaka ImaiTohoku Institute for Management of Blood Pressure (K.A., T.O., Y.I.).
Thomas VanasscheCentre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.V., P.V.).
Peter VerhammeCentre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (T.V., P.V.).
Stefan JanssensDivision of Cardiology, Department of Internal Medicine, University Hospitals Leuven, Belgium (S.J.).
Eoin O'BrienConway Institute, University College Dublin, Ireland (E.O.).
Gladys E MaestreLaboratory of Neurosciences, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela (J.D.M., G.E.M).
Jan A StaessenFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
Zhen-Yu ZhangFrom the Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., W.-Y. Y, L.T., F.-F.W., J.A.S., Z.-Y.Z.).
International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcome Investigators*
KU Leuven · BEUniversidad del Zulia · VERuijin Hospital · CNUniversity College Dublin · IETeikyo University · JPUniversity of Padua · ITGdańsk Medical University · PLJagiellonian University · PLCharles University · CZInstitute of Cytology and Genetics · RUShanghai Jiao Tong University · CNSociety of General Internal Medicine · USSport Ireland · IESteno Diabetes Centers · DKUniversidad de la República de Uruguay · UYUppsala University · SE

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0M
Gene-Environment Interactions in Cognition in Venezuelan FamiliesR01AG036469 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHACON, INARA, MAESTRE, GLADYS E. · 2011 to 2015
$2.7M
A longitudinal study of mid-to late-life blood pressure profiles as risk factors for Alzheimer´s disease in HispanicsR03AG054186 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAESTRE, GLADYS E., TERWILLIGER, JOSEPH DOUGLAS · 2016 to 2017
$163k
NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG036469NIA NIH HHS R03 AG054186
6 · The paper itself

Abstract

Major adverse cardiovascular events are closely associated with 24-hour blood pressure (BP). We determined outcome-driven thresholds for 24-hour mean arterial pressure (MAP), a BP index estimated by oscillometric devices. We assessed the association of major adverse cardiovascular events with 24-hour MAP, systolic BP (SBP), and diastolic BP (DBP) in a population-based cohort (n=11 596). Statistics included multivariable Cox regression and the generalized R

Indexed as

Blood Pressure Monitoring, AmbulatoryAdultAgedCardiovascular DiseasesFemaleHumansHypertensionMaleMiddle AgedProportional Hazards Modelscardiovascular diseasehypertensionmean arterial pressuremortalityoscillometry

Identifiers

PMID33296250
PMCPMC7720872
OpenAlexW3112142863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.