Evidence map›Paper›PMID 33296226›Full record

ArticleMolecular biology of the cell2021

Costameric integrin and sarcoglycan protein levels are altered in a

Simranjot Bawa, Samantha Gameros, Kenny Baumann, David S Brooks, Joseph A Kollhoff, Michal Zolkiewski, Andrea David Re Cecconi, Nicolò Panini, Massimo Russo, Rosanna Piccirillo and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Simranjot BawaDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Samantha GamerosDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Kenny BaumannSchool of Biological Sciences, University of Missouri-Kansas City, MO 64110.
David S BrooksDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Joseph A KollhoffDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Michal ZolkiewskiDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Andrea David Re CecconiDepartment of Neuroscience and.
Nicolò PaniniDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Massimo RussoDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Rosanna PiccirilloDepartment of Neuroscience and.
David K JohnsonMolecular Graphics and Modeling Laboratory, Computational Chemical Biology Core, University of Kansas, Lawrence, KS 66047.
Maithri M KashipathyProtein Structure Laboratory, University of Kansas, Lawrence, KS 66047.
Kevin P BattaileNYX, New York Structural Biology Center, Upton, NY 11973.
Scott LovellProtein Structure Laboratory, University of Kansas, Lawrence, KS 66047.
Samuel E A BouyainSchool of Biological Sciences, University of Missouri-Kansas City, MO 64110.
Jessica KawakamiSchool of Biological Sciences, University of Missouri-Kansas City, MO 64110.
Erika R GeisbrechtDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Kansas State University · USUniversity of Missouri–Kansas City · USUniversity of Kansas · USMario Negri Institute for Pharmacological Research · ITNew York Structural Biology Center · US

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
Mechanisms Underlying Muscle Development in DrosophilaR01AR060788 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI Erika Rae Geisbrecht · 2012 to 2026
$4.3M
Metabolic defects promote pathogenesis in a Drosophila model of muscular dystrophyR21AR073373 · NIAMS · KANSAS STATE UNIVERSITY · PI GEISBRECHT, ERIKA RAE · 2018 to 2019
$364k
Protein Tyrosine Phosphatase Signaling in Muscle MaintenanceR21AR066264 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI BOUYAIN, SAMUEL · 2014 to 2015
$358k
NIAMS NIH HHS R01 AR060788NIAMS NIH HHS R21 AR066264NIAMS NIH HHS R21 AR073373NIGMS NIH HHS P20 GM113117NIGMS NIH HHS P30 GM110761
6 · The paper itself

Abstract

Mutations in two different domains of the ubiquitously expressed TRIM32 protein give rise to two clinically separate diseases, one of which is Limb-girdle muscular dystrophy type 2H (LGMD2H). Uncovering the muscle-specific role of TRIM32 in LGMD2H pathogenesis has proven difficult, as neurogenic phenotypes, independent of LGMD2H pathology, are present in

Indexed as

AnimalsAnimals, Genetically ModifiedCostameresDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsHumansIntegrinsMuscle, SkeletalMuscular Dystrophies, Limb-GirdleMutationMyofibrilsNeurogenesisPhenotypeSarcoglycansTranscription FactorsDrosophila ProteinsIntegrinsSarcoglycanstn protein, DrosophilaTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID33296226
PMCPMC8098830
OpenAlexW3112637941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.