Evidence map›Paper›PMID 33296124›Full record

ArticleJournal of clinical laboratory analysis2021

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculosis drug-induced hepatotoxicity: A prospective study.

Yuhui Cheng, Lin Jiao, Weixiu Li, Jialing Wang, Zhangyu Lin, Hongli Lai, Binwu Ying

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuhui ChengWest China School of Medicine, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-9270-0781
Lin JiaoWest China School of Medicine, Sichuan University, Chengdu, China.
Weixiu LiWest China School of Medicine, Sichuan University, Chengdu, China.
Jialing WangWest China School of Medicine, Sichuan University, Chengdu, China.
Zhangyu LinWest China School of Medicine, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-9240-9724
Hongli LaiWest China School of Medicine, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-7146-3518
Binwu YingWest China School of Medicine, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-7828-1453
Sichuan University · CN

Funding

National Science & Technology Pillar Program during the 13th Five-year Plan Period 2018ZX10715003
6 · The paper itself

Abstract

backgroundThe role of collagen type XVIII alpha 1 chain (COL18A1) in anti-tuberculosis drug-induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility.

methodsA total of 746 patients were enrolled in our study from December 2016 to April 2018, and all subjects in the study signed an informed consent form. The custom-by-design 2x48-Plex SNPscanTM kit was used to genotype all selected 11 SNPs. Categorical variables were compared by chi-square (χ

resultsAmong patients with successfully genotyping, there were 114 cases and 612 controls. The mutant A allele of rs12483377 conferred the decreased risk of ATDH (OR = 0.13, 95%CI: 0.02-0.98, P = 0.020), and this significance still existed after adjusting age and gender (P = 0.024). The mutant homozygote AA genotype of rs12483377 was associated with decreased total protein levels (P = 0.018).

conclusionOur study first revealed that the A allele of COL18A1 rs12483377 was associated with the decreased risk of ATDH in the Western Chinese Han population, providing new perspective for the molecular prediction, precise diagnosis, and individual treatment of ATDH.

Indexed as

AdultAntitubercular AgentsAsian PeopleChemical and Drug Induced Liver InjuryCollagen Type XVIIIFemaleGene FrequencyHaplotypesHumansLogistic ModelsMaleMiddle AgedPolymorphism, Single NucleotideProspective StudiesAntitubercular AgentsCOL18A1 protein, humanCollagen Type XVIIIanti-tuberculosis drug-induced hepatotoxicityCOL18A1genetic polymorphismssusceptibility

Identifiers

PMID33296124
PMCPMC7891502
OpenAlexW3113112784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.