ArticleInsights into imaging2020
Lean body weight versus total body weight to calculate the iodinated contrast media volume in abdominal CT: a randomised controlled trial.
Article in Insights into imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03384979 (Randomized Controlled Trial of Optimization of Contrast Agent Dose in CT With Lean Body Weight), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Optimization of Contrast Agent Dose in CT With Lean Body Weight
Who cites it
11 citing papers in PubMed.
- Lean body weight-based contrast injection protocol in liver CT: optimization of contrast medium dose.La Radiologia medica · 2025Trial
- Iodinated Contrast Media Dose Protocols for Computed Tomography Investigations of the Abdomen: A Systematic Review and Meta-Analysis.Journal of imaging · 2026Review
- Optimization of high-concentration (400 mgI/mL) contrast media volume for abdominal computed tomography: a comparison between fixed-dose and total body weight-based protocols.Quantitative imaging in medicine and surgery · 2026Article
- Utilizing Opportunistic Computed Tomography Imaging to Refine Lean Body Weight Estimates in Patients with Obesity.Clinical pharmacokinetics · 2025Article
- Validation of a multi-parameter algorithm for personalized contrast injection protocol in liver CT.European radiology experimental · 2024Article
- Strategies for calculating contrast media dose for chest CT.European radiology experimental · 2023Article
- Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol.European radiology experimental · 2023Article
- Individualized scan protocols for CT angiography: an animal study for contrast media or radiation dose optimization.European radiology experimental · 2023Article
- Lean body weight-adjusted intravenous iodinated contrast dose for abdominal CT in dogs reduces interpatient enhancement variability while providing diagnostic quality organ enhancement.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2022Article
- Individualized Contrast Media Application Based on Body Weight and Contrast Enhancement in Computed Tomography of Livers without Steatosis.Diagnostics (Basel, Switzerland) · 2022Article
- Liver Enhancement on Computed Tomography Is Suboptimal in Patients with Liver Steatosis.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIodinated contrast media (ICM) could be more appropriately dosed on patient lean body weight (LBW) than on total body weight (TBW).
methodsAfter Ethics Committee approval, trial registration NCT03384979, patients aged ≥ 18 years scheduled for multiphasic abdominal CT were randomised for ICM dose to LBW group (0.63 gI/kg of LBW) or TBW group (0.44 gI/kg of TBW). Abdominal 64-row CT was performed using 120 kVp, 100-200 mAs, rotation time 0.5 s, pitch 1, Iopamidol (370 mgI/mL), and flow rate 3 mL/s. Levene, Mann-Whitney U, and χ
resultsOf 335 enrolled patients, 17 were screening failures; 44 dropped out after randomisation; 274 patients were analysed (133 LBW group, 141 TBW group). The median age of LBW group (66 years) was slightly lower than that of TBW group (70 years). Although the median ICM-injected volume was comparable between groups, its variability was larger in the former (interquartile range 27 mL versus 21 mL, p = 0.01). The same was for unenhanced liver density (IQR 10 versus 7 HU) (p = 0.02). Median LCE was 40 (35-46) HU in the LBW group and 40 (35-44) HU in the TBW group, without significant difference for median (p = 0.41) and variability (p = 0.23). Suboptimal LCE (< 40 HU) was found in 64/133 (48%) patients in the LBW group and 69/141 (49%) in the TBW group, but no examination needed repeating.
conclusionsThe calculation of the ICM volume to be administered for abdominal CT based on the LBW does not imply a more consistent LCE.
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