Evidence map›Paper›PMID 33295882›Full record

ArticleThe Journal of endocrinology2021

Tissue selective effects of bazedoxifene on the musculoskeletal system in female mice.

Christine A Cabelka, Cory W Baumann, Angus Lindsay, Andrew Norton, Nick C Blixt, Gengyun Le, Gordon L Warren, Kim C Mansky, Susan A Novotny, Dawn A Lowe

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christine A CabelkaDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Cory W BaumannDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Angus LindsayDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Andrew NortonDepartment of Developmental and Surgical Sciences, University of Minnesota, School of Dentistry, Minneapolis, Minnesota, USA.
Nick C BlixtDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Gengyun LeDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Gordon L WarrenDepartment of Physical Therapy, Georgia State University, Atlanta, Georgia, USA.
Kim C ManskyDepartment of Developmental and Surgical Sciences, University of Minnesota, School of Dentistry, Minneapolis, Minnesota, USA.
Susan A NovotnyDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USCollege of St. Scholastica · USGeorgia State University · USGillette Children's Specialty Healthcare · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Musculoskeletal Training GrantT32AR050938 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CLOHISY, DENIS R · 2004 to 2020
$3.0M
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and MalesR01AG062899 · NIA · UNIVERSITY OF MINNESOTA · PI KYBA, MICHAEL, LOWE, DAWN A · 2019 to 2023
$2.5M
NIAMS NIH HHS T32 AR007612NIAMS NIH HHS T32 AR050938NIA NIH HHS R01 AG031743NIA NIH HHS R01 AG062899NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

The actions of selective estrogen receptor modulators are tissue dependent. The primary objective of the current study was to determine the tissue selective effects of bazedoxifene (BZA) on the musculoskeletal system of ovariectomized (OVX) female mice, focusing on the strengths of muscle-bone pairs in the lower hindlimb. Treatment with BZA after ovariectomy (OVX+BZA) did not prevent body or fat mass gains (P < 0.05). In vivo plantarflexor muscle isometric torque was not affected by treatment with BZA (P = 0.522). Soleus muscle peak isometric, concentric and eccentric tetanic force production were greater in OVX+BZA mice compared to OVX+E2 mice (P ≤ 0.048) with no effect on maximal isometric specific force (P = 0.228). Tibia from OVX+BZA mice had greater cortical cross-sectional area and moment of inertia than OVX mice treated with placebo (P < 0.001), but there was no impact of BZA treatment on cortical bone mineral density, cortical thickness, tibial bone ultimate load or stiffness (P ≥ 0.086). Overall, these results indicate that BZA may be an estrogen receptor agonist in skeletal muscle, as it has previously been shown in bone, providing minor benefits to the musculoskeletal system.

Indexed as

AnimalsDrug Evaluation, PreclinicalEstrogensFemaleIndolesMiceMice, Inbred C57BLMotor ActivityMuscle ContractionMusculoskeletal SystemOvariectomyRandom AllocationSelective Estrogen Receptor ModulatorsTibiabazedoxifeneEstrogensIndolesSelective Estrogen Receptor Modulatorsboneovariectomyphysical activitySERMskeletal muscle

Identifiers

PMID33295882
PMCPMC7933086
OpenAlexW3112024614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.