Evidence map›Paper›PMID 33295150›Full record

ArticleHIV medicine2021

Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV.

M Bogorodskaya, A Lyass, T F Mahoney, L H Borowsky, P Sen, F K Swirski, S Srinivasa, C T Longenecker, J M Massaro, R B D'Agostino and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

M BogorodskayaDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6809-0984
A LyassDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
T F MahoneyDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
L H BorowskyDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
P SenDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
F K SwirskiCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
S SrinivasaProgram in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1950-4770
C T LongeneckerCase Western Reserve University School of Medicine, Cleveland, OH, USA.
J M MassaroDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
R B D'AgostinoDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
V A TriantDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Boston University · USHarvard University · USMassachusetts General Hospital · USBeth Israel Deaconess Medical Center · USUniversity School · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Enhancing cardiovascular risk estimation in individuals aging with HIV/HCV co-infectionR01AG062393 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI TRIANT, VIRGINIA ATHENA · 2019 to 2023
$4.5M
Optimizing Cardiovascular Risk Prediction in HIVR01HL132786 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI D'AGOSTINO, RALPH B, TRIANT, VIRGINIA ATHENA · 2017 to 2020
$3.5M
Physiologic Investigation of the Renin-Angiotensin-Aldosterone System to Understand Arterial Inflammation in HIVK23HL136262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SRINIVASA, SUMAN · 2017 to 2021
$960k
NCATS NIH HHS UL1 TR001102NHLBI NIH HHS K23 HL136262NHLBI NIH HHS R01 HL132786NIA NIH HHS R01 AG062393
6 · The paper itself

Abstract

objectivesCardiovascular risk is increased in people living with HIV (PLWH). In HIV-uninfected populations, total absolute monocyte count (AMC) has been shown to be predictive of future cardiovascular events (CVEs). We sought to determine whether AMC predicts CVEs in PLWH independent of established and HIV-related cardiovascular risk factors.

methodsWe identified all PLWH within the Partners HIV Cohort without factors that could confound the monocyte count. CVE was defined as fatal or non-fatal acute myocardial infarction or ischaemic stroke. Baseline-measured AMC was defined as the average of all outpatient AMC counts a year before and after the baseline date. Multivariable Cox proportional hazards models were used to assess the association of baseline AMC with CVEs.

resultsOur cohort consisted of 1980 patients, with median follow-up of 10.9 years and 182 CVEs. Mean (± SD) age was 41.9 ± 9.3 years; 73.0% were male. Mean CD4 count was 506.3 ± 307.1 cells/µL, 48% had HIV viral load (VL) < 400 copies/mL, and 87% were on antiretroviral therapy. Mean AMC was 0.38 × 10 DISCUSSION: Baseline AMC was not associated with long-term CVEs in PLWH. AMC obtained in routine clinical encounters does not appear to enhance CV risk stratification in PLWH.

Indexed as

Brain IschemiaHIV InfectionsStrokeAdultHumansMaleMiddle AgedMonocytesRetrospective Studiesabsolute monocyte countcardiovascular diseasecardiovascular riskHIVmonocyte immune activation

Identifiers

PMID33295150
PMCPMC7954843
OpenAlexW3112826546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.