Evidence map›Paper›PMID 33295134›Full record

Observational studyESC heart failure2021

Prevalence and prognostic value of the coexistence of anaemia and frailty in older patients with heart failure.

Shinya Tanaka, Kentaro Kamiya, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo and 14 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Observational
  6. Anemia in heart failure: evidence from a three-year cross-sectional study in Sudan.Journal of pharmaceutical health care and sciences · 2025
    Article
  7. Article
  8. Observational
  9. The Dual Burden of Frailty and Heart Failure.International journal of heart failure · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Shinya TanakaDepartment of Rehabilitation, Nagoya University Hospital, Aichi, Japan.
Kentaro KamiyaDepartment of Rehabilitation, School of Allied Health Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
Hiroshi SaitoDepartment of Rehabilitation, Kameda Medical Center, Chiba, Japan.
Kazuya SaitoDepartment of Rehabilitation, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
Yuki OgasaharaDepartment of Nursing, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
Emi MaekawaDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Masaaki KonishiDivision of Cardiology, Yokohama City University Medical Center, Kanagawa, Japan.
Takeshi KitaiDepartment of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan.
Kentaro IwataDepartment of Rehabilitation, Kobe City Medical Center General Hospital, Hyogo, Japan.
Kentaro JujoDepartment of Cardiology, Nishiarai Heart Center Hospital, Tokyo, Japan.
Hiroshi WadaDepartment of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Takatoshi KasaiDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Nobuaki HamazakiDepartment of Rehabilitation, Kitasato University Hospital, Kanagawa, Japan.
Kohei NozakiDepartment of Rehabilitation, Kitasato University Hospital, Kanagawa, Japan.
Hirofumi NagamatsuDepartment of Cardiology, Tokai University School of Medicine, Tokyo, Japan.
Tetsuya OzawaDepartment of Rehabilitation, Odawara Municipal Hospital, Kanagawa, Japan.
Katsuya IzawaDepartment of Rehabilitation, Kasukabe Chuo General Hospital, Saitama, Japan.
Shuhei YamamotoDepartment of Rehabilitation, Shinshu University Hospital, Nagano, Japan.
Naoki AizawaDepartment of Cardiovascular Medicine, Nephrology and Neurology, University of Ryukyus, Okinawa, Japan.
Kazuki WakaumeDepartment of Rehabilitation, Kitasato University Medical Center, Saitama, Japan.
Kazuhiro OkaDepartment of Rehabilitation, Saitama Citizens Medical Center, Saitama, Japan.
Shin-Ichi MomomuraSaitama Citizens Medical Center, Saitama, Japan.
Nobuyuki KagiyamaDepartment of Cardiology, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
Yuya MatsueDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThere have been no investigations of the prevalence and clinical implications of coexistence of anaemia and frailty in older patients hospitalized with heart failure (HF) despite their association with adverse health outcomes. The present study was performed to determine the prevalence and prognostic value of the coexistence of anaemia and frailty in hospitalized older patients with HF. METHODS AND

resultsWe performed post hoc analysis of consecutive hospitalized HF patients ≥65 years old enrolled in the FRAGILE-HF, which was the prospective, multicentre, observational study. Anaemia was defined as haemoglobin < 13 g/dL in men and <12 g/dL in women, and frailty was evaluated according to the Fried phenotype model. The study endpoint was all-cause mortality. Of the total of 1332 patients, 1217 (median age, 81 years; 57.4% male) were included in the present study. The rates of anaemia and frailty in the study population were 65.7% and 57.0%, respectively. The patients were classified into the non-anaemia/non-frail group (16.6%), anaemia/non-frail group (26.4%), non-anaemia/frail group (17.7%), and anaemia/frail group (39.3%). A total of 144 patients died during 1 year of follow-up. In multivariate analyses, only the anaemia/frail group showed a significant association with elevated mortality rate (adjusted hazard ratio, 1.94; 95% confidence interval, 1.02-3.70; P = 0.043), compared with the non-anaemia/non-frail group after adjusting for other covariates.

conclusionsCoexistence of anaemia and frailty are prevalent in hospitalized older patients with HF, and it has a negative impact on mortality.

Indexed as

AnemiaFrailtyHeart FailureAgedAged, 80 and overFemaleFrail ElderlyHumansMalePrevalencePrognosisProspective StudiesAnaemiaFrailtyGeriatricsHeart failure in elderlyPrognosis

Identifiers

PMID33295134
PMCPMC7835564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.