Evidence map›Paper›PMID 33295018›Full record

ArticleMuscle & nerve2021

Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.

Donovan J Lott, Tanja Taivassalo, Korey D Cooke, Hyunjun Park, Zahra Moslemi, Abhinandan Batra, Sean C Forbes, Barry J Byrne, Glenn A Walter, Krista Vandenborne

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Article
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  8. Observational
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  11. Article
  12. Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  13. Article
  14. Article
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  16. Magnetic Resonance Imaging Biomarkers of Muscle.Tomography (Ann Arbor, Mich.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Donovan J LottDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Tanja TaivassaloDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA.
Korey D CookeDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Hyunjun ParkDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Zahra MoslemiDepartment of Applied Physiology & Kinesiology, University of Florida, Gainesville, Florida, USA.
Abhinandan BatraDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Sean C ForbesDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Barry J ByrneDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.
Glenn A WalterDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA.
Krista VandenborneDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
University of Florida · US

Funding

Magnetic Resonance Imaging and Biomarkers for Muscular DystropyR01AR056973 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2010 to 2024
$20.2M
Development of a Strength Training Protocol in Duchenne Muscular DystrophyR21AR064949 · NIAMS · UNIVERSITY OF FLORIDA · PI LOTT, DONOVAN J · 2014 to 2015
$363k
NIAMS NIH HHS R01 AR056973NIAMS NIH HHS R21 AR064949
6 · The paper itself

Abstract

backgroundThis two-part study explored the safety, feasibility, and efficacy of a mild-moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).

methodsFirst, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12-wk in-home, remotely supervised, mild-moderate intensity strengthening program in eight boys. Safety measures included T

resultsDose-escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12-wk in-home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05).

conclusionsAn in-home, mild-moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.

Indexed as

ExerciseChildCreatine KinaseExercise TherapyFeasibility StudiesHamstring MusclesHumansMagnetic Resonance ImagingMaleMuscle, SkeletalMuscle StrengthMuscular Dystrophy, DuchenneQuadriceps MuscleTreatment OutcomeCreatine KinaseDuchenne muscular dystrophyfunctional abilityin-home exercise programisometric exerciseT2 MRI

Identifiers

PMID33295018
PMCPMC9254904
OpenAlexW3111323068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.