Evidence map›Paper›PMID 33294984›Full record

ArticleMuscle & nerve2021

Reduced plasmablast frequency is associated with seronegative myasthenia gravis.

Jeffrey T Guptill, Richard Barfield, Cliburn Chan, Melissa A Russo, Doug Emmett, Shruti Raja, Janice M Massey, Vern C Juel, Lisa D Hobson-Webb, Karissa L Gable and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Jeffrey T GuptillNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Richard BarfieldDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
Cliburn ChanDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.
Melissa A RussoNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Doug EmmettNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Shruti RajaNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0003-0216-1564
Janice M MasseyNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Vern C JuelNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Lisa D Hobson-WebbNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Karissa L GableNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Natalia GonzalezNeuromuscular Division, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.
Alex HammettDuke Clinical Research Institute, Durham, North Carolina, USA.
James F HowardNeuromuscular Disorders Section, Department of Neurology, The University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-7136-8617
Manisha ChopraNeuromuscular Disorders Section, Department of Neurology, The University of North Carolina, Chapel Hill, North Carolina, USA.
Henry J KaminskiDepartment of Neurology, George Washington University, Washington, District of Columbia, USA.
Zaeem A SiddiqiDivision of Neurology, University of Alberta, Edmonton, Alberta, Canada.
Mattingly MigdalThe University of North Carolina, Chapel Hill, North Carolina, USA.
John S YiDivision of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · USClinical Research Institute · USDuke University · USGeorge Washington University · USUniversity of Alberta · CA

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
Immunological biomarker studies in myasthenia gravisK23NS085049 · NINDS · DUKE UNIVERSITY · PI GUPTILL, JEFFREY T · 2014 to 2018
$924k
NCATS NIH HHS UL1 TR002553NINDS NIH HHS K23 NS085049
6 · The paper itself

Abstract

backgroundThe immunopathology of autoimmune seronegative myasthenia gravis (SN MG) is poorly understood. Our objective was to determine immune profiles associated with a diagnosis of SN MG.

methodsWe performed high-dimensional flow cytometry on blood samples from SN MG patients (N = 68), healthy controls (N = 46), and acetylcholine receptor antibody (AChR+) MG patients (N = 27). We compared 12 immune cell subsets in SN MG to controls using logistic modeling via a discovery-replication design. An exploratory analysis fit a multinomial model comparing AChR+ MG and controls to SN MG.

resultsAn increase in CD19

conclusionsReduced plasmablast frequencies are strongly associated with a SN MG diagnosis and may be a useful diagnostic biomarker in the future.

Indexed as

AdultAgedAutoantibodiesBiomarkersFemaleFlow CytometryHumansMaleMiddle AgedMyasthenia GravisPlasma CellsReceptors, CholinergicYoung AdultAutoantibodiesBiomarkersReceptors, CholinergicAChRbiomarkersmyasthenia gravisplasmablastsseronegative

Identifiers

PMID33294984
PMCPMC8100987
OpenAlexW3110953994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.