Evidence map›Paper›PMID 33294965›Full record

ArticleResearch on child and adolescent psychopathology2021

Irritability Predicts Hyperactive/Impulsive Symptoms Across Adolescence for Females.

Sarah Kahle, Prerona Mukherjee, J Faye Dixon, Ellen Leibenluft, Stephen P Hinshaw, Julie B Schweitzer

Open access · greenAbstract read
In one paragraph

Article in Research on child and adolescent psychopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sarah KahleMIND Institute, University of California, Davis, CA, USA.ORCID 0000-0003-4749-4936
Prerona MukherjeeMIND Institute, University of California, Davis, CA, USA.
J Faye DixonMIND Institute, University of California, Davis, CA, USA.
Ellen LeibenluftEmotion and Development Branch, NIMH, Bethesda, MD, USA.
Stephen P HinshawUniversity of California, Berkeley, CA, USA.
Julie B SchweitzerMIND Institute, University of California, Davis, CA, USA. jschweitzer@ucdavis.edu.
University of California, Davis · USUniversity of California, San Francisco · USUniversity of California System · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Developmental Changes in Neural Processes Underlying Inattention, Impulsivity and RegulationR01MH091068 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHWEITZER, JULIE B. · 2012 to 2022
$7.4M
NICHD NIH HHS U54 HD079125NIMH NIH HHS R01 MH091068
6 · The paper itself

Abstract

Irritability is common in Attention-Deficit Hyperactivity Disorder (ADHD), but little is known about whether irritability predicts the course of ADHD symptoms over time. Adolescence is a dynamic period of emotional development as well as shifts in ADHD symptoms; an important goal is to identify youth at risk of increasing or persisting symptoms. We examined irritability as a longitudinal predictor of change in adolescents' ADHD symptoms, as well as how this link may differ in females versus males. The sample included 108 youth (72 males) age 12-16 years (M = 14.21 years, SD = 1.44 years), 62 of whom met criteria for ADHD. Approximately 18 months later, 80 participants (48 males) were followed up at Time 2. A dimensional approach was used to examine changes over time in parent-reported inattentive and hyperactive/impulsive symptoms. Longitudinal path analysis revealed that irritability at Time 1 predicted higher relative hyperactive/impulsive symptoms at Time 2 after controlling for age and longitudinal stability in all variables. A multiple-group analysis examining moderation by sex/gender revealed that this association was significant only for females. These results suggest that irritability may play a key role in the persistence and worsening of hyperactive/impulsive symptoms across adolescence for females, with potential implications for the diagnosis and treatment of females with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityImpulsive BehaviorAdolescentAttentionChildFemaleHumansIrritable MoodMalePsychomotor AgitationAdolescenceAttention-deficit hyperactivity disorder (ADHD)Emotion dysregulationGenderIrritabilitySex

Identifiers

PMID33294965
PMCPMC8202810
OpenAlexW3109916963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.