Evidence map›Paper›PMID 33294869›Full record

ArticlePatterns (New York, N.Y.)2020

Virtual Monoenergetic CT Imaging via Deep Learning.

Wenxiang Cong, Yan Xi, Paul Fitzgerald, Bruno De Man, Ge Wang

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Canadian radiology: 2025 update.Japanese journal of radiology · 2025
    Review
  3. Dual-energy CT-based virtual monoenergetic imaging via unsupervised learning.Physical and engineering sciences in medicine · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Systematic Review on Learning-based Spectral CT.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Estimating optical parameters of biological tissues with photon-counting micro-CT.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Advances in micro-CT imaging of small animals.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Wenxiang CongBiomedical Imaging Center, Center for Biotechnology & Interdisciplinary, Department of Biomedical Engineering, School of Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Yan XiShanghai First-Imaging Tech, Shanghai, China.
Paul FitzgeraldGE Research, One Research Circle, Niskayuna, NY 12309, USA.
Bruno De ManGE Research, One Research Circle, Niskayuna, NY 12309, USA.
Ge WangBiomedical Imaging Center, Center for Biotechnology & Interdisciplinary, Department of Biomedical Engineering, School of Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
GE Global Research (United States) · USImaging Center · USRensselaer Polytechnic Institute · US

Funding

Cardiac CT DebloomingR01HL151561 · NHLBI · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI BUDOFF, MATTHEW J, DE MAN, BRUNO · 2020 to 2023
$3.8M
In vivo Macroscopic Fluorescence Lifetime Molecular Optical ImagingR01CA250636 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2020 to 2023
$2.9M
Photon-counting X-ray and Optical Tomography for Preclinical Cancer ResearchR01CA237267 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2019 to 2023
$2.9M
Life time imaging with pulsed x-ray based x-ray luminescence computed tomographyR01EB026646 · NIBIB · UNIVERSITY OF CALIFORNIA, MERCED · PI LI, CHANGQING · 2018 to 2021
$2.6M
NCI NIH HHS R01 CA237267NCI NIH HHS R01 CA250636NHLBI NIH HHS R01 HL151561NIBIB NIH HHS R01 EB026646
6 · The paper itself

Abstract

Conventional single-spectrum computed tomography (CT) reconstructs a spectrally integrated attenuation image and reveals tissues morphology without any information about the elemental composition of the tissues. Dual-energy CT (DECT) acquires two spectrally distinct datasets and reconstructs energy-selective (virtual monoenergetic [VM]) and material-selective (material decomposition) images. However, DECT increases system complexity and radiation dose compared with single-spectrum CT. In this paper, a deep learning approach is presented to produce VM images from single-spectrum CT images. Specifically, a modified residual neural network (ResNet) model is developed to map single-spectrum CT images to VM images at pre-specified energy levels. This network is trained on clinical DECT data and shows excellent convergence behavior and image accuracy compared with VM images produced by DECT. The trained model produces high-quality approximations of VM images with a relative error of less than 2%. This method enables multi-material decomposition into three tissue classes, with accuracy comparable with DECT.

Indexed as

computed tomographyCTmachine learningMMDmulti-material decompositionvirtual monoenergetic imagingVM

Identifiers

PMID33294869
PMCPMC7691386
OpenAlexW3093199996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.