Evidence map›Paper›PMID 33294857›Full record

ArticleCell reports. Medicine2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Miqdad O Dhariwala, Dhuvarakesh Karthikeyan, Kimberly S Vasquez, Sepideh Farhat, Antonin Weckel, Keyon Taravati, Elizabeth G Leitner, Sean Clancy, Mariela Pauli, Merisa L Piper and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  8. Article
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  11. Article
  12. Review
  13. Tissue regulatory T cells: regulatory chameleons.Nature reviews. Immunology · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miqdad O DhariwalaDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Dhuvarakesh KarthikeyanDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kimberly S VasquezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Sepideh FarhatDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Antonin WeckelDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Keyon TaravatiDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Elizabeth G LeitnerDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Sean ClancyDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Mariela PauliDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Merisa L PiperDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Jarish N CohenDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Judith F AshouriRosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Margaret M LoweDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tiffany C ScharschmidtDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Signaling and repertoire differences in arthritogenic T cellsK08AR072144 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHOURI, JUDITH · 2018 to 2022
$887k
NIAID NIH HHS T32 AI007334NIAMS NIH HHS K08 AR072144NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, we utilized mass and flow cytometry to elucidate early features of human skin immunity. Although most conventional αβ T (Tconv) cells in fetal skin have a naive, proliferative phenotype, a subset of CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFlow CytometryHumansImmunologic MemoryInterferon-gammaLymphocyte ActivationSkinT-Lymphocytes, RegulatoryInterferon-gammafetalhair follicle developmenthuman skinlymphocytesmemory T cellsskin developmentTregs

Identifiers

PMID33294857
PMCPMC7691438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.