Evidence map›Paper›PMID 33294829›Full record

ReviewJHEP reports : innovation in hepatology2021

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy.

Amin Mahpour, Alan C Mullen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Spatial genomics: mapping human steatotic liver disease.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  14. Review
  15. A nomogram based on 4-lncRNAs signature for improving prognostic prediction of hepatocellular carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  16. HCC-Related lncRNAs: Roles and Mechanisms.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Amin MahpourGastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Alan C MullenGastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Long noncoding RNAs regulating liver fibrosisR01DK116999 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALAN C MULLEN · 2019 to 2026
$2.2M
NIDDK NIH HHS R01 DK116999
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.

Indexed as

ABCA1, ATP-binding cassette transporter A1ACTA2/ɑ-SMA, α-smooth muscle actinAPO, apolipoproteinASO, antisense oligonucleotidesBDL, bile duct ligationCCA, cholangiocarcinomaCCl4, carbon tetrachlorideceRNA, competing endogenous RNACholangiocarcinomaCOL1A1, collagen type I α 1CYP, cytochrome P450DANCR, differentiation antagonising non-protein coding RNADEANR1, definitive endoderm-associated lncRNA1DE, definitive endodermDIGIT, divergent to goosecoid, induced by TGF-β family signallingDILC, downregulated in liver cancer stem cellsEpCAM, epithelial cell adhesion moleculeeRNA, enhancer RNAsEST, expression sequence tagFBP1, fructose-bisphosphatase 1FENDRR, foetal-lethal non-coding developmental regulatory RNAFXR, farnesoid X receptorGAS5, growth arrest-specific transcript 5H3K18ac, histone 3 lysine 18 acetylationH3K36me3, histone 3 lysine 36 trimethylationH3K4me3, histone 3 lysine 4 trimethylationHCC, hepatocellular carcinomaHEIH, high expression In HCCHepatocellular carcinomaHNRNPA1, heterogenous nuclear protein ribonucleoprotein A1HOTAIR, HOX transcript antisense RNAHOTTIP, HOXA transcript at the distal tipHSC, hepatic stellate cellsHULC, highly upregulated in liver cancerHuR, human antigen RLCSC, liver cancer stem cellLeXis, liver-expressed LXR-induced sequencelincRNA, long intervening non-coding RNALiver cancerLiver fibrosisLiver metabolismLiver-specific lncRNAsLncLSTR, lncRNA liver-specific triglyceride regulatorlncRNAlncRNA, long non-coding RNALSD1, lysine-specific demethylase 1LXR, liver X receptorsMALAT1, metastasis-associated lung adenocarcinoma transcript 1MEG3, maternally expressed gene 3mTOR, mammalian target of rapamycinNAT, natural antisense transcriptNEAT1, nuclear enriched abundant transcript 1ORF, open reading framePKM2, pyruvate kinase muscle isozyme M2PPAR-α, peroxisome proliferator-activated receptor-αPRC, polycomb repressive complexRACE, rapid amplification of cDNA endsRNA Pol, RNA polymeraseS6K1, S6 kinase 1SHP, small heterodimer partnersiRNA, small interfering RNASREBPs, steroid response binding proteinsSREs, sterol response elementsTGF-β, transforming growth factor-βTTR, transthyretinXIST, X-inactive specific transcriptZEB1, zinc finger E-box-binding homeobox 1

Identifiers

PMID33294829
PMCPMC7689550
OpenAlexW3083612906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.