Evidence map›Paper›PMID 33294739›Full record

ArticleJACC. Basic to translational science2020

β-Arrestin-Biased AT

Toshihide Kashihara, Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Shin Kadota, Elena E Wolf, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto, Mitsuhiko Yamada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Biased Allosteric Modulation in GPCR Drug Discovery.Handbook of experimental pharmacology · 2026
    Review
  2. Review
  3. Insights Into the Role of Angiotensin-II ATHypertension (Dallas, Tex. : 1979) · 2024
    Review
  4. Angiotensin ATCell reports · 2023
    Article
  5. Review
  6. Review
  7. Comparative evaluation of biased agonists SarcosinePharmacology research & perspectives · 2023
    Article
  8. Review
  9. Article
  10. Potential of ATJACC. Basic to translational science · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Toshihide KashiharaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Hiroyuki KawagishiDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Tsutomu NakadaDepartment of Instrumental Analysis, Research Center for Supports to Advanced Science, Shinshu University, Matsumoto, Japan.
Takuro Numaga-TomitaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Shin KadotaDepartment of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.
Elena E WolfDivision of Nephrology and Division of Vascular Endothelium and Microcirculation, Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Cheng-Kun DuDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Yuji ShibaDepartment of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.
Sachio MorimotoSchool of Health Sciences Fukuoka, International University of Health and Welfare, Okawa, Japan.
Mitsuhiko YamadaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Shinshu University · JPInternational University of Health and Welfare · JPNational Cerebral and Cardiovascular Center · JPUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca

Indexed as

AngII, angiotensin IIAT1R, angiotensin type 1 receptorBBA, β-arrestin–biased angiotensin type 1 receptor agonistcongenital dilated cardiomyopathyECG, electrocardiographyGPCR, G protein–coupled receptorhiPSC-CM, human induced pluripotent stem cell–derived cardiac myocytehuman induced pluripotent stem cell-derived cardiac myocytesinotropic vasodilatorLTCC, CaV1.2 L-type Ca2+ channelmNVCM, mouse neonatal ventricular cardiac myocyteneonateOCR, oxygen consumption ratepediatric heart failurePHF, pediatric heart failureROS, reactive oxygen speciesTRV027UCG, ultrasound cardiogramβ-arrestin–biased AT1 angiotensin receptor agonist

Identifiers

PMID33294739
PMCPMC7691286
OpenAlexW3104419960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.