ArticleClinical and translational radiation oncology2021
Dose-dependent volume loss in subcortical deep grey matter structures after cranial radiotherapy.
Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Stereotactic or Whole Brain Radiotherapy on Neurocognitive Functioning in Adult Patients with Brain Metastases: A Systematic Review and Meta-Analysis.Oncology research and treatment · 2021Pooled it
- Negative impact of hippocampal radiotherapy dose on memory function in patients with brain metastases.Neuro-oncology practice · 2026Article
- Longitudinal cortical thickness changes in children with posterior fossa tumors.Neuro-oncology practice · 2026Article
- Decreased overall survival in patients with brain metastases from non-small cell lung cancer with radiotherapy dose on the neurogenic niches.Technical innovations & patient support in radiation oncology · 2026Article
- Gray Matter Volumetry and Cognitive Functioning in Pediatric Posterior Fossa Tumor Survivors.Cancers · 2026Article
- Hippocampal Atrophy Following Therapeutic Irradiation of Intracranial and Nasopharyngeal Tumors.Cureus · 2025Review
- Subcortical alterations following pediatric posterior fossa brain tumor treatment: A longitudinal MRI study.Neuroimage. Reports · 2025Article
- Advanced Neuroimaging and Emerging Systemic Therapies in Glioblastoma: Current Evidence and Future Directions.Biomedicines · 2025Review
- Systematic comparison of semi-automated VBM pipelines for assessing chemoradiotherapy effects on the tumoural and non-tumoural brain in glioblastoma multiforme.Magma (New York, N.Y.) · 2025Article
- Radiotherapy-induced neurocognitive decline among adult intracranial tumor patients: A voxel-based approach.Neuro-oncology · 2025Article
- Potential Risk of Cognitive Impairment Due to Irradiation of Neural Structures in Locally Advanced Nasopharyngeal Cancer Treated by Curative Radiotherapy.Medicina (Kaunas, Lithuania) · 2025Article
- Longitudinal brain volumetrics in glioma survivors.Journal of neurosurgery · 2024Article
- Remote assessment of cognition and quality of life following radiotherapy for nasopharyngeal carcinoma: deep-learning-based predictive models and MRI correlates.Journal of cancer survivorship : research and practice · 2024Article
- Individualized trajectories in postradiotherapy neurocognitive functioning of patients with brain metastases.Neuro-oncology practice · 2024Article
- Volumetric brain assessment of long-term head and neck cancer survivors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2024Article
- Artificial intelligence and radiation effects on brain tissue in glioblastoma patient: preliminary data using a quantitative tool.La Radiologia medica · 2023Article
- Review
- Remote assessment of cognition and quality of life following radiotherapy for glioma: deep-learning-based predictive models and MRI correlates.Journal of neuro-oncology · 2023Article
- Voxel based morphometry-detected white matter volume loss after multi-modality treatment in high grade glioma patients.PloS one · 2023Article
- Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy.Clinical and translational radiation oncology · 2022Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe relation between radiotherapy (RT) dose to the brain and morphological changes in healthy tissue has seen recent increased interest. There already is evidence for changes in the cerebral cortex and white matter, as well as selected subcortical grey matter (GM) structures. We studied this relation in all deep GM structures, to help understand the aetiology of post-RT neurocognitive symptoms. MATERIALS AND
methodsWe selected 31 patients treated with RT for grade II-IV glioma. Pre-RT and 1 year post-RT 3D T1-weighted MRIs were automatically segmented, and the changes in volume of the following structures were assessed: amygdala, nucleus accumbens, caudate nucleus, hippocampus, globus pallidus, putamen, and thalamus. The volumetric changes were related to the mean RT dose received by each structure. Hippocampal volumes were entered into a population-based nomogram to estimate hippocampal age.
resultsA significant relation between RT dose and volume loss was seen in all examined structures, except the caudate nucleus. The volume loss rates ranged from 0.16 to 1.37%/Gy, corresponding to 4.9-41.2% per 30 Gy. Hippocampal age, as derived from the nomogram, was seen to increase by a median of 11 years.
conclusionAlmost all subcortical GM structures are susceptible to radiation-induced volume loss, with higher volume loss being observed with increasing dose. Volume loss of these structures is associated with neurological deterioration, including cognitive decline, in neurodegenerative diseases. To support a causal relationship between radiation-induced deep GM loss and neurocognitive functioning in glioma patients, future studies are needed that directly correlate volumetrics to clinical outcomes.
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