Evidence map›Paper›PMID 33294464›Full record

ReviewJournal of immunology research2020

The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases.

Lin Li, Panyang Xu, Qi Zhou, Jiancheng Xu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Antibody Cross-Reactivity in Auto-Immune Diseases.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lin LiDepartment of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-0368-4095
Panyang XuDepartment of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-2895-9112
Qi ZhouDepartment of Pediatrics, First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-5084-8697
Jiancheng XuDepartment of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0001-8796-271X
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimmune liver diseases (AILDs). TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. TFH cells also downregulate chemokine (C-C motif) receptor 7 and promote the dysregulation of the T follicular regulatory/TFH axis. This review highlights the importance of TFH cells in AILDs.

Indexed as

AnimalsAutoimmune DiseasesBiomarkersCytokinesDiagnosis, DifferentialDisease SusceptibilityHumansInflammation MediatorsLiver DiseasesT Follicular Helper CellsBiomarkersCytokinesInflammation Mediators

Identifiers

PMID33294464
PMCPMC7691009
OpenAlexW3098355941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.