Evidence map›Paper›PMID 33294415›Full record

ArticleRestorative dentistry & endodontics2020

Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an

Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Restorative dentistry & endodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope.International journal of biomaterials · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fábio Rocha BohnsDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0001-9355-1570
Vicente Castelo Branco LeituneDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-5415-1731
Isadora Martini GarciaDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-7388-0200
Bruna GenariDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-6329-9543
Nélio Bairros DornellesDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-6799-7015
Silvia Stanisçuaski GuterresCosmetology Laboratory, School of Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-6085-6826
Fabrício Aulo OgliariYller Biomaterials, Pelotas, RS, Brazil.ORCID https://orcid.org/0000-0002-2965-445X
Mary Anne Sampaio de MeloProgram in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-0007-2966
Fabrício Mezzomo CollaresDepartment of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-1382-0150
Universidade Federal do Rio Grande do Sul · BRUniversidade Federal de Pelotas · BRUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement. MATERIALS AND

methodsAmoxicillin-loaded microspheres were synthesized by a spray-dray method and incorporated at 2.5% and 5% into a mineral trioxide aggregate cement clinically used to induce a mineralized barrier at the root tip of young permanent teeth with incomplete root development and necrotic pulp. The formulations were modified in liquid:powder ratios and in composition by the microspheres. The optimized formulations were evaluated

resultsThe optimized cement formulation containing microspheres at 5% exhibited a delayed-release response and maintained its fundamental functional properties. When mixed with amoxicillin-loaded microspheres, the setting times of both test materials significantly increased. The diametral tensile strength of cement containing microspheres at 5% was similar to control. However, phytic acid had no effect on this outcome (

conclusionsLack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.

Indexed as

Aggregate trioxide mineralAmoxicillinDental materialsEndodonticsMicrospheres

Identifiers

PMID33294415
PMCPMC7691264
OpenAlexW3091999349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.