ArticleEvolutionary applications2020
Incorporating genetic selection into individual-based models of malaria and other infectious diseases.
Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions.Nature medicine · 2025Article
- Risk of selection and timelines for the continued spread of artemisinin and partner drug resistance in Africa.medRxiv : the preprint server for health sciences · 2024Article
- Evolutionary rescue in resistance to pesticides.Proceedings. Biological sciences · 2024Article
- Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus modelling study.The Lancet. Microbe · 2022Article
- Article
- Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa.Malaria journal · 2021Article
- Incorporating genetic selection into individual-based models of malaria and other infectious diseases.Evolutionary applications · 2020Article
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4 authors.
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Abstract
introductionControl strategies for human infections are often investigated using individual-based models (IBMs) to quantify their impact in terms of mortality, morbidity and impact on transmission. Genetic selection can be incorporated into the IBMs to track the spread of mutations whose origin and spread are driven by the intervention and which subsequently undermine the control strategy; typical examples are mutations which encode drug resistance or diagnosis- or vaccine-escape phenotypes. METHODS AND
resultsWe simulated the spread of malaria drug resistance using the IBM OpenMalaria to investigate how the finite sizes of IBMs require strategies to optimally incorporate genetic selection. We make four recommendations. Firstly, calculate and report the selection coefficients, DISCUSSION: The OpenMalaria IBM of malaria was an exemplar and the same principles apply to IBMs of other diseases.
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