Evidence map›Paper›PMID 33293902›Full record

ReviewJournal of interventional cardiology2020

Thermodilution-Based Invasive Assessment of Absolute Coronary Blood Flow and Microvascular Resistance: Quantification of Microvascular (Dys)Function?

Daniëlle C J Keulards, Mohamed El Farissi, Pim A L Tonino, Koen Teeuwen, Pieter-Jan Vlaar, Eduard van Hagen, Inge F Wijnbergen, Annemiek de Vos, Guus R G Brueren, Marcel Van't Veer and 1 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of interventional cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07380919 (Inhibition of Late Sodium Current), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07380919 phase2 / phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: A Multicenter, Randomized, Controlled and Open Label Study (INaMICRON Study)

TypeinterventionalSponsorFederico II UniversityRan2026 to 2026Enrolled100ConditionsSTEMI (ST Elevation MI)ArmsRanolazine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Changes in coronary collateral function after successful chronic total occlusion percutaneous coronary intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Daniëlle C J KeulardsCatharina Hospital, Eindhoven, Netherlands.ORCID https://orcid.org/0000-0002-0913-4967
Mohamed El FarissiCatharina Hospital, Eindhoven, Netherlands.ORCID https://orcid.org/0000-0002-0637-0796
Pim A L ToninoCatharina Hospital, Eindhoven, Netherlands.ORCID https://orcid.org/0000-0002-2099-5426
Koen TeeuwenCatharina Hospital, Eindhoven, Netherlands.
Pieter-Jan VlaarCatharina Hospital, Eindhoven, Netherlands.
Eduard van HagenCatharina Hospital, Eindhoven, Netherlands.
Inge F WijnbergenCatharina Hospital, Eindhoven, Netherlands.
Annemiek de VosCatharina Hospital, Eindhoven, Netherlands.
Guus R G BruerenCatharina Hospital, Eindhoven, Netherlands.
Marcel Van't VeerCatharina Hospital, Eindhoven, Netherlands.
Nico H J PijlsCatharina Hospital, Eindhoven, Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the last two decades, there has been a sharp increase in both interest and knowledge about the coronary microcirculation. Since these small vessels are not visible by the human eye, physiologic measurements should be used to characterize their function. The invasive methods presently used (coronary flow reserve (CFR) and index of microvascular resistance (IMR)) are operator-dependent and mandate the use of adenosine to induce hyperemia. In recent years, a new thermodilution-based method for measurement of absolute coronary blood flow and microvascular resistance has been proposed and initial procedural problems have been overcome. Presently, the technique is easy to perform using the Rayflow infusion catheter and the Coroventis software. The method is accurate, reproducible, and completely operator-independent. This method has been validated noninvasively against the current golden standard for flow assessment: Positron Emission Tomography-Computed Tomography (PET-CT). In addition, absolute flow and resistance measurements have proved to be safe, both periprocedurally and at long-term follow-up. With an increasing number of studies being performed, this method has great potential for better understanding and quantification of microvascular disease.

Indexed as

MicrocirculationCoronary CirculationCoronary VesselsHumansMyocardial IschemiaReproducibility of ResultsThermodilutionVascular Resistance

Identifiers

PMID33293902
PMCPMC7688370
OpenAlexW3099578519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.